ABSTRACT
Background: Aerobic exercise stimulates the release of beta- endorphin and other endogenous opioid peptides that are induced influences of morphine and other receptors agonist's opioid peptides. Therefore, it may be reduced withdrawal sign and benefit in withdrawal period. The purpose of this study was investigated acute effects of swimming exercise on common behavior following withdrawal syndrome in morphine-dependent rats
Method: in this experimental study Male Wistar rats [250 +/- 20 g, N=24] in two group [control addiction, exercise trained addiction] were addicted by morphine sulfate 0.4 mg/ml [for 21 days] and animals were submitted to swimming training for 8 weeks;they initially swim 60 min for 3 weeks, then 90 min 2 weeks, finally 120 min for 3 weeks. At the end of each stage of exercise protocol we inject naloxan hydrochloride [3mg/kg.ip]. Behavioral symptoms [such as jumping, tearing, teeth chattering, diarrhea, and body tremors] were measured based on 45-minute in addicted animal. Analysis of variance with repeated measures [with the software SPSS] was used to analyze the data
Results: Our data showed that swimming exercise after 5 and 8 weeks acutely decreased withdrawal sign [p<0.05]. Withdrawal sign did not significantly change after 3 weeks of swimming exercise in addicted rats
Conclusion: Our data showed that swimming exercise after 8 weeks decreased Behavioral signs. Therefore, it can be used for the treatment and/or management of withdrawal conditions