The Influence of Family History on Stage and Survival of Gastric Cancer According to the

Background/Aims@#The survival rate of gastric cancer (GC) is known to be higher in patients with a family history (FH) of GC. There is an association between a polymorphism in the transforming growth factor-β1 (

Viperin Differentially Induces Interferon-Stimulated Genes in Distinct Cell Types

Viperin is an IFN-stimulated gene (ISG)-encoded protein that was identified in human primary macrophages treated with IFN-γ and in human primary fibroblasts infected with cytomegalovirus (CMV). This protein plays multiple roles in various cell types. It inhibits viral replication, mediates signaling pathways, and regulates cellular metabolism. Recent studies have shown that viperin inhibits IFN expression in macrophages, while it enhances TLR7 and TLR9-mediated IFN production in plasmacytoid dendritic cells, suggesting that viperin can play different roles in activation of the same pathway in different cell types. Viperin also controls induction of ISGs in macrophages. However, the effect of viperin on induction of ISGs in cell types other than macrophages is unknown. Here, we show that viperin differentially induces ISGs in 2 distinct cell types, macrophages and fibroblasts isolated from wild type and viperin knockout mice. Unlike in bone marrow-derived macrophages (BMDMs), viperin downregulates the expression levels of ISGs such as bone marrow stromal cell antigen-2, Isg15, Isg54, myxovirus resistance dynamin like GTPase 2, and guanylate binding protein 2 in murine embryonic fibroblasts (MEFs) treated with type I or II IFN. However, viperin upregulates expression of these ISGs in both BMDMs and MEFs stimulated with polyinosinic-polycytidylic acid or CpG DNA and infected with murine CMV. The efficiency of viral entry is inversely proportional to the expression levels of ISGs in both cell types. The data indicate that viperin differentially regulates induction of ISGs in a cell type-dependent manner, which might provide different innate immune responses in distinct cell types against infections.

Viperin Deficiency Promotes Polarization of Macrophages and Secretion of M1 and M2 Cytokines

Viperin is a multifunctional protein that was first identified in human primary macrophages treated with interferon-γ and in human fibroblasts infected with human cytomegalovirus. This protein plays a role as an anti-viral protein and a regulator of cell signaling pathways or cellular metabolism when induced in a variety of cells such as fibroblasts, hepatocytes and immune cells including T cells and dendritic cells. However, the role of viperin in macrophages is unknown. Here, we show that viperin is basally expressed in murine bone marrow cells including monocytes. Its expression is maintained in bone marrow monocyte-derived macrophages (BMDMs) depending on macrophage colony-stimulating factor (M-CSF) treatment but not on granulocyte-macrophage colony-stimulating factor (GM-CSF) treatment. In wild type (WT) and viperin knockout (KO) BMDMs differentiated with M-CSF or G-MCSF, there are little differences at the gene expression levels of M1 and M2 macrophage markers such as inducible nitric oxide synthase (iNOS) and arginase-1, and cytokines such as IL-6 and IL-10, indicating that viperin expression in BMDMs does not affect the basal gene expression of macrophage markers and cytokines. However, when BMDMs are completely polarized, the levels of expression of macrophage markers and secretion of cytokines in viperin KO M1 and M2 macrophages are significantly higher than those in WT M1 and M2 macrophages. The data suggest that viperin plays a role as a regulator in polarization of macrophages and secretion of M1 and M2 cytokines.

Predictive Factors for Improvement of Atrophic Gastritis and Intestinal Metaplasia: A Long-term Prospective Clinical Study

BACKGROUND/AIMS: To investigate the predictive factors for improvement of atrophic gastritis (AG) and intestinal metaplasia (IM). MATERIALS AND METHODS: A total of 778 subjects were prospectively enrolled and followed up for 10 years. Histological analysis of AG and IM was performed by using the updated Sydney system. To find the predictive factors for reversibility of AG and IM, 24 factors including genetic polymorphisms and bacterial and environmental factors were analyzed. RESULTS: In all subjects, the predictive factor by multivariate analysis for improvement of both antral and corpus AG was successful eradication. The predictive factors for improvement of antral IM were age and successful eradication. The predictive factor for improvement of corpus IM was successful eradication. In patients with Helicobacter pylori infection, age and cagA were predictive factors for improvement of AG and IM. In patients with H. pylori eradication, monthly income and cagA were predictive factors for improvement of AG and IM. CONCLUSIONS: H. pylori eradication is an important predictive factor of regression of AG and IM and would be beneficial for the prevention of intestinal-type gastric cancer. Young age, high income, and cagA are additional predictive factors for improving AG and IM status. Thus, various factors affect the improvement of AG and IM.

Validation of Prediction Models for Mismatch Repair Gene Mutations in Koreans / Journal of the Korean Cancer Association, 대한암학회지

PURPOSE: Lynch syndrome, the commonest hereditary colorectal cancer syndrome, is caused by germline mutations in mismatch repair (MMR) genes. Three recently developed prediction models for MMR gene mutations based on family history and clinical features (MMRPredict, PREMM1,2,6, and MMRPro) have been validated only in Western countries. In this study, we propose validating these prediction models in the Korean population. MATERIALS AND METHODS: We collected MMR gene analysis data from 188 individuals in the Korean Hereditary Tumor Registry. The probability of gene mutation was calculated using three prediction models, and the overall diagnostic value of each model compared using receiver operator characteristic (ROC) curves and area under the ROC curve (AUC). Quantitative test characteristics were calculated at sensitivities of 90%, 95%, and 98%. RESULTS: Of the individuals analyzed, 101 satisfied Amsterdam criteria II, and 87 were suspected hereditary nonpolyposis colorectal cancer. MMR mutations were identified in 62 of the 188 subjects (33.0%). All three prediction models showed a poor predictive value of AUC (MMRPredict, 0.683; PREMM1,2,6, 0.709; MMRPro, 0.590). Within the range of acceptable sensitivity (> 90%), PREMM1,2,6 demonstrated higher specificity than the other models. CONCLUSION: In the Korean population, overall predictive values of the three models (MMRPredict, PREMM1,2,6, MMRPro) for MMR gene mutations are poor, compared with their performance in Western populations. A new prediction model is therefore required for the Korean population to detect MMR mutation carriers, reflecting ethnic differences in genotype-phenotype associations.

Influence of bone loss pattern on stress distribution in bone and implant: 3D-FEA study / 대한치과보철학회지

PURPOSE: This 3D-FEA study was performed to investigate the influence of marginal bone loss pattern around the implant to the stress distribution. MATERIAL AND METHODS: From the right second premolar to the right second molar of the mandible was modeled according to the CT data of a dentate patient. Teeth were removed and an implant (small ef, Cyrillic 4.0 x 10.0 mm) was placed in the first molar area. Twelve bone models were created: Studied bone loss conditions were horizontal bone loss and vertical bone loss, assumed bone loss patterns during biologic width formation, and pathologic vertical bone loss with or without cortification. Axial, buccolingual, and oblique force was applied independently to the center of the implant crown. The Maximum von Mises stress value and stress contour was observed and von Mises stresses at the measuring points were recorded. RESULTS: The stress distribution patterns were similar in the non-resorption and horizontal resorption models, but differed from those in the vertical resorption models. Models assuming biologic width formation showed altered stress distribution, and weak bone to implant at the implant neck area seams accelerates stress generation. In case of vertical bone resorption, contact of cortical bone to the implant may positively affect the stress distribution.

The assessment of abutment screw stability between the external and internal hexagonal joint under cyclic loading / 대한치과보철학회지

STATEMENT OF PROBLEM: Currently, many implant systems are developed and divided into two types according to their joint connection: external or internal connection. Regardless of the connection type, screw loosening is the biggest problem in implant-supported restoration. PURPOSE: The purpose of this study is to assess the difference in stability of abutment screws between the external and internal hexagonal connection types under cyclic loading. MATERIAL AND METHODS: Each of the 15 samples of external implants and internal abutments were tightened to 30 N/cm with a digital torque gauge, and cemented with a hemispherical metal cap. Each unit was then mounted in a 30degrees. inclined jig. Then each group was divided into 2 sub-groups based on different periods of cyclic loading with the loading machine (30 N/ cm - 300 N/cm,14 Hz: first group 1 x 10(6), 5 x 10(6) cyclic loading; second group 3 x 10(6), 3 x 10(6) for a total cyclic loading of 6 x 10(6) The removal torque value of the screw before and after cyclic loading was checked. SPSS statistical software for Windows was used for statistical analysis. Group means were calculated and compared by ANOVA, independent t-test, and paired t-test with alpha = 0.05. RESULTS: In the external hexagonal connection, the difference between the removal torque value of the abutment screw before loading, the value after 1 x 10(6) cyclic loading, and the value after 1 x 10(6), and additional 5 x 10(6) cyclic loading was not significant. The difference between the removal torque value after 3 x 10(6) cyclic loading and after 3 x 10(6), and additional 3 x 10(6) cyclic loading was not significant. In the internal hexagonal connection, the difference between the removal torque value before loading and the value after 1 x 10(6) cyclic loading was not significant, but the value after 1 x 10(6), and additional 5 x 10(6) cyclic loading was reduced and the difference was significant (P < .05). In addition, in the internal hexagonal connection, the difference between the removal torque value after 3 x 10(6) cyclic loading and the value after 3 x 10(6), and additional 3 x 10(6) cyclic loading was not significant. CONCLUSION: The external hexagonalconnection was more stable than the internal hexagonal connection after 1 x 10(6), and additional 5 x 10(6) cyclic loading (t = 10.834, P < .001). There was no significant difference between the two systems after 3 x 10(6), and additional 3 x 10(6) cycles.

A comparative study of the amount of displacement and occlusion forms in the change from CR to CO / 대한치과보철학회지

STATEMENT OF PROBLEMS: The concept of CR has also changed continuously. In order to find out the factors that affect the centric slide, studies were carried out to compare the forms of wisdom teeth eruption, lateral movement, premature contact in CR, and anterior movement. Research and statistical methods were based on the report by the 1980 Korean dental association. MATERIAL AND METHOD: In our study, 403 dentists in their twenties and dentistry students who could understand CR and CO (and who did not receive occlusal, orthodontic treatment, without extreme caries and large prosthodontic care) were compared with the 25 year old results. A segment of line parallel to the upper incisor was marked on the lower incisor. When seen laterally, a line perpendicular to the occlusal plane was drawn on the foremost area of the upper incisor. This line was extended to the lower incisor and the two points (points at the lower and upper incisors) were used as reference points for the CO. After guiding the occlusion to the CR, two lines were marked by using the same method that was used for the CO. The point in which these lines meet became the reference point of CR occlusion. RESULTS AND CONCLUSIONS: Results of the experiment completed in 1980 show that all 307 research members had anterior-posterior and upper-lower displacement. Displacement measurements were 0.7+/-0.4 mm for the anterior-posterior displacement, 0.99+/-0.50 mm for the upper-lower displacement,0.18+/-0.31 mm for the lateral displacement, and 1.32+/-0.67 mm for the total displacement. Results of the 2006 experiment show that all 409 research members had anterior-posterior and upper-lower displacement. The anterior-posterior displacement was 1.12+/-0.86 mm, the upper-lower displacement was 1.02+/-0.71 mm, the lateral displacement was 0.61+/-0.56 mm, and the total displacement was 1.80+/-0.99 mm. No specific differences were found between each group when comparing displacement according to the forms of wisdom teeth eruption. Since 1980, the percentage of unerupted teeth has increased from 35.16% (111/307 people) to 57.5% (236/409 people). Westernization of the Korean cranial form and intraoral structure has brought about these results. In our experiment, 26.7% (109/409 people) of the subjects were cuspid guided, while 7.3% (30/409 people) were mutually guided. No specific differences were found in the amount of displacement between the two groups. Only the subjects with anteriors coming in contact made up the largest percentage group (42.3%, 173/409 people) in our study. No specific differences were found between each group.

An influence of abutment materials on a screw-loosening after cyclic loading / 대한치과보철학회지

STATEMENT OF PROBLEM: A phenomenon of screw-loosening in implant abutment is frequently occurred in a single and multiple implant restoration. PURPOSE: This study was performed to evaluate an effect of abutment material on screw-loosening before and after a cyclic loading. In a single-tooth implant , different materials of abutment, Type III Gold alloy and Zirconium composite(ZrO2/Al2O3) were used. MATERIAL AND METHOD: The Gold alloy(Type III) and Zirconium composite(ZrO2/Al2O3) were used to make a superstructure of implant, the one of types of UCLA, Each group was constituted of 5 sample with a 30-degree offset angulated loading platform. The external hexagonal fixture was rigidly hel d in a special holding zig to ensure solid fixation without rotation during the tightening and a cyclic loading. A Titanium-alloy screw was used to connect and controlled to be tighten in 20Ncm torque by a digital torque gauge. A 20 times of consecutive closing/opening cycle were performed to evaluate the immediate torque loss. In 5 sample of each material group, an initial opening torque was recorded during 3 closing/opening cycle, then 2Hz, 200N, 1,000,000 cyclic loadings were performed, then a opening torque was evaluated. RESULT & CONCLUSION: 1. In this limited study, titanium alloy screw tightened in 20Ncm, a cold-welding phenomen on was not observed during the 20 times of closing/opening cycle(p=0.11, p=0.18). 2. In titanium alloy abutment screw, repeated opening and closing of the screw caused to progressive decrease of opening torque(p=0.014). 3. The difference in preload of screw between gold alloy abutment and ceramic(ZrO2/Al2O3) abutment was not significant(p=0.78). 4. The difference in torque loss of screw between gold alloy abutment and ceramic(ZrO2/Al2O3) abutment was not significant after 2Hz,200N, 1,000,000 cyclic loading(p=0.92). 5. In titanium alloy abutment screw tightened by 20Ncm, the screw loosening was not significant on each group after 2Hz, 200Ncm, 1,000,000 cyclic loading(p=0.59).

A study on the marginal fit of collarless metal ceramic fixed partial dentures / 대한치과보철학회지

STATEMENT OF PROBLEM: Collarless metal ceramic fixed partial dentures(FPDs) had an esthetic problem such as opaque reflection in cervical region. To overcome this, modified coping which removed its facial cervical metal could be used. The marginal quality could be worsen according to the amount of its facial metal reduction. PURPOSE: The purpose of this study was to evaluate marginal fits of collarless metal ceramic FPDs with retainers of modified copings. MATERIAL AND METHOD: Dentoform maxillary left central incisor and right lateral incisor were prepared for 3-unit collarless metal ceramic FPD and fixed in yellow stone. This model was duplicated to PBT resin dies via CAD/CAM and injection molding. Four different facial margin design groups were investigated. Group A was a coping with a thin facial metal collar, group B was a collarless coping with its facial metal to the shoulder, group C was a collarless coping with its facial metal 1 mm short of the shoulder, and group D was a collarless coping with its facial metal 2 mm short of the shoulder. Seven collarless metal ceramic FPDs per group were fabricated. They were cemented to PBT resin dies with resin cement. After removal of pontics, each retainers were separated and observed under Accura 2000 optical microscope. Then, retainers were embeded in orthodontic resin and cross sectioned faciopalatally. Internal marginal fits of midfacial porcelain margins were observed under FE-SEM. Result and CONCLUSION. Within the limitations of this in vitro study. The following conclusions were drawn. 1. Mean marginal gaps of collarless FPDs were in the 50-60 micrometer range. 2. In midfacial margin, marginal discrepancies were greater in group A than in the experimental groups(p<0.05). 3. In midpalatal margin, marginal gaps were greater in group C and D than in group A and B(p<0.05). 4. Marginal fits of porcelain margins were better than those of metal margins in collarless metal ceramic FPDs. 5. In both teeth, internal marginal gaps of group C and D were greater than those of group A and B(p<0.05).

A Clinical Analysis of Surgical Treatment for Axillary Osmidrosis by the Bipedicle Flap Method and CO2 Laser / 대한피부과학회지

BACKGROUND: Axillary osmidrosis is caused by excessive secretion of apocrine sweat, which causes foul odor and extreme social embarrassment. Axillary osmidrosis can be treated by a number of methods, but surgery is the treatment of choice. OBJECTIVE: The purpose of this study was to evaluate clinical results of surgical treatment for axillary osmidrosis by the bipedicle flap method and CO2 laser. METHODS: December 1995 and December 2002, 53 patients with axillary osmidrosis were treated by the bipedicle flap method and with CO2 laser. Post-operative complications and convalescent time in the patients (106 axillae) were then of evaluated. Among them, 37 patients were followed up for a minimum 6 months, and the patients were asked to complete a questionnaire on their family history, aggravation factors, association with wet ear wax or palmoplantar hyperhidrosis, degree of satisfaction, decreased sweating, decreased axillary hair, tension on motion, and scarring. RESULTS: Follow-up ranged from 6 to 84 months (mean: 41months). Thirty one (83.8%) out of 37 patients were satisfied or partially satisfied with the results. Six (16.2%) out of 37 patients were dissatisfied. Post-operative complications were seen in 27 (25.5%) out of 106 axillae. The average convalescent time was 18 days. CONCLUSION: Based on the long-term evaluation, this bipedicle flap method and CO2 laser treatment were found to be effective for axillary osmidrosis.

A Case of Tufted Angioma Arising within a Nevus Flammeus / 대한피부과학회지

Tufted angioma is an uncommon, slowly-progressive vascular tumor, found typically in infants, young children and sometimes at birth or during adulthood. It shows a characteristic histopathologic finding, the so-called "cannonball" appearance. Various tumors can be developed in the nevus flammeus, such as pyogenic granuloma, basal cell carcinoma, squamous cell carcinoma, giant proliferative hemangioma and lymphangioma circumscriptum. Tufted angioma can be also accompanied with nevus flammeus and the coexistence of tufted angioma and nevus flammeus is a very rare condition. We report a case of tufted angioma arising within nevus flammeus in the left axilla of a 47 year-old female.

A Case of ReVersible MRI and SPECT Abnormalities in the Neocortex of the Temporal and Parietal Lobes after a Generalized Seizure

We report a case with reVersible temporal and parietal neocortical abnormalities detected by MRI and SPECT following a brief seizure. Post ictal MRI abnormalities may indicate an underlying structural abnormality, but may also occur in non-lesional epilepsy and represent a transient physiologic change induced by ictal activity.

Expression of Microbial Receptors and Production of Cytokine in Mouse Keratinocyte Cells in Response to Lipopolysaccharide Stimulation / 대한피부과학회지

BACKGROUND: Microbial receptors play an important role in host defense. Microbial receptors- Toll-like receptor 4 (TLR4), CD14, CD11b, and CD18-mediate the responsiveness to Gram-negative lipopolysaccharide (LPS). The host response to LPS is characterized by an influx of inflammatory cells into host tissues, which is mediated, in part, by localized production of cytokines. Although the expression of microbial receptors and production of cytokines in macrophages are well studied, the functional responses of keratinocytes to stimulation with LPS are not well known. OBJECTIVES: We investigated the expression of microbial receptors and production of cytokine in response to LPS in mouse keratinocytes. METHODS: RAW264.7 cells, mouse macrophage cell line, were used as a positive control. Balbc/mk and PAM212 cells, mouse keratinocyte cell lines, were checked for the expression of microbial receptors and production of cytokine in response to LPS stimulation by flow cytometry and ELISA. RESULTS: RAW264.7 cells constitutively expressed high levels of TLR4, CD14, CD11b, and CD18. Balbc/mk and PAM212 cells also constitutively expressed high levels of CD14 and TLR4 similarily with RAW264.7 cells, but the levels of CD11b and CD18 expression was constitutively low. LPS stimulation resulted in increased production of TNF-alpha in RAW264.7 cells and mouse KC in mouse keratinocytes. In addition, LPS stimulation induced up-regulation of TLR4, CD14, CD11b, and CD18 in RAW264.7 cells, and TLR4 and CD14 in mouse keratinocytes. Anti-receptor specific antibodies efficiently blocked mouse KC production in mouse keratinocytes stimulated by low-dose LPS (100ng/ml). CONCLUSION: Taken together, these results indicate that mouse keratinocytes constitutively express microbial receptors and produce cytokine in response to LPS stimulation. Therefore, keratinocytes can actively participate in innate immunity against pathogens by secreting inflammatory cytokines through microbial receptor recognition.

Marginal fit of the auro galvano crown system made using the electroforming technique / 대한치과보철학회지

STATEMENT OF PROBLEM: There have been few studies about the marginal fit of Auro Galvano Crowns. PURPOSE: The purpose of this study was to compare the marginal fit of the anterior single restorations. MATERIAL AND METHODS: The in vitro marginal discrepancies of metal-ceramic, Auro Galvano Crown and coping were evaluated and compared. The Auro Gavano Crowns were made from one extracted maxillary central incisor prepared by milling machine. 30crowns per each system were fabricated. Measurements of a crown were recorded at 50 points that were randomly selected for marginal gap evaluation. Parametric statistical analysis was performed for the results. RESULTS: Mean marginal gap dimensions and standard deviations at the marginal opening for the anterior single crowns were 74+/-21micrometer for the control (metal-ceramic restoration), 45+/-11 micrometer for Auro Galvano Crown coping, and 51+/-9 micrometer for the Auro Galvano Crown. CONCLUSIONS: Auro Galvano Crown showed significantly smaller (P .05)

A Case of Breast Reduction with Pure Tumescent Liposuction / 대한피부과학회지

Patients with macromastia have physical discomfort including head, neck, and shoulder pain, wet skin fold/eczema, intractable mastalgia, and restricted exercise. They also have cosmetic problems and psychiatric discomfort. In Korea, excisional breast reduction is the main treatment option for macromastia, but breast reduction with pure tumescent liposuction is becoming a new treatment option in western society. Breast reduction with pure tumescent liposuction has multiple advantages including safety, no general anesthesia, outpatient procedure, minimal scaring, no loss of nipple sensation and the possibility of breast feeding. We report a case of macromastia treated by pure tumescent liposuction without any sedation. We hope that this article may help Korean dermatologists to understand about breast reduction using pure tumescent liposuction and expand the field of dermatologic surgery in Korean society.

A Case of Fibroadenoma Arising in the Accessory Breast Tissue of the Axilla / 대한피부과학회지

Accessory breast tissue of the axilla is one of the varieties of supernumerary breast tissue, which is observed after puberty. The tissue is capable of developing identical pathophysiologic changes as normal breast tissue. The pathologic findings of the accessory breast tissue were classified as normal breast tissue, cystic disease, chronic mastitis, atypical ductal hyperplasia, and fibroadenoma. Among these, the fibroadenoma is relatively uncommon. We have experienced a case of fibroadenoma arising in the accessory breast tissue of the axilla. A 28-year-old woman had a 8-month history of 1.5x1.3cm and 1.1x1.2cm sized firm nodules, deeply located in subcutaneous tissue on the left axilla. The size of the lesion was constant. However, she complained of mild tenderness at every premenstrual period. The histopathologic finding of the lesion revealed the typical features of fibroadenoma with accessory breast tissue.

The Significance of Prophylactic Antibiotics in Skin Biopsy / 대한피부과학회지

BACKGROUND: Many dermatologists usually prescribe antibiotics postoperatively to prevent the wound infection, but there are no definite guidelines for the use of prophylactic antibiotics in skin biopsy. OBJECTIVE: The purpose of this study is to evaluate the efficacy of prophylactic antibiotics after skin biopsy. METHODS: We performed the prospective study of 200 patients in skin biopsy. We excluded patients who have a risk factor of infective endocarditis, replacement of articular prosthesis within 6 months, chronic renal failure, chronic hepatic failure, anemia, internal malignancy, untreated diabetes, immune suppression, taken antibiotic within 1 week, hypersensitivity to antibiotics and infected wound. They were classified randomly into two groups, each 100 patients with or without antibiotic prophylaxis. All patient received the wound dressing. All biopsy wounds were evaluated in a blinded fashion at the time of suture removal and scored according to a standardized assessment based on erythema, edema and discharge. RESULTS: Of the 100 patients who received the wound dressing and the prophylactic antibiotics postoperatively, no one had surgical wound infection. Of the 100 patients who received only the wound dressing, one patient had surgical wound infection. CONCLUSION: The infection rates were not significantly different between two groups. Therefore prophylactic antibiotics after skin biopsy may not be necessary to prevent wound infection in healthy patients.

A Familial Outbreak of Food-borne Botulism

We experienced 3 cases of food-borne botulism within a family. They presented with progressive ptosis, dysphonia, dysarthria and limb weakness, which had started about 12 hours after ingestion of vacuum-packed sausage. Two cases progressed to respiratory failure. Botulinum toxin A was detected from the stool sample of one case. Conservative treatment with mechanical ventilation was done and they recovered from respiratory failure over a 30-70 days period. This is the first case report of food-borne botulism in Korea.

Immediate Reconstruction of Defects Caused by Mohs Surgery of Skin Cancer / 대한피부과학회지

BACKGROUND: Mohs surgery is an increasingly appealing option for skin cancer. It is traditionally performed by a Mohs dermatologist, followed by a secondary repair by a head and neck or plastic surgeon. But one-stage procedure Mohs surgery with immediate reconstruction enhances patient's satisfaction and reduces the need for more than one procedure or multiple postoperative visits. OBJECT: The purpose of this study was to report our experience of Mohs surgery and immediate reconstruction by a dermatologist. Results, complications, and recurrence rates were reviewed. METHODS: Seventy five skin cancers, which were treated by Mohs surgery and reconstructed immediately were analysed retrospectively. RESULT: There were 43 females and 32 males. The mean age was 62.2. Basal cell carcinoma was the most common skin tumor. The Nose was the most common anatomic site. The mean size of tumor was 1.8cm. The local flap was the most common used to repair surgical defects. Complications were minimal. Recurrent cases were none during 40-months follow up (range, 12-58 months). CONCLUSION: Immediate one-stage reconstruction after Mohs surgery by a dermatologist is a safe, convenient method to treat skin cancers.