ABSTRACT
Objective To investigate the epidemiological characteristics of COPD in people over 60 years old in Chaohu City, Anhui Province, and explore the risk factors affecting the occurrence and development of COPD, and to provide a data basis for formulating prevention and control measures of COPD. Methods Permanent residents over 60 years old in Chaohu City were selected as the research subjects. The subjects were selected by multi-stage stratified cluster random sampling method. All research subjects were divided into two different groups according to the diagnostic criteria of COPD and received questionnaire survey and pulmonary function tests. The differences in epidemiological distribution of the two groups were compared by χ2 test. Logistics regression was used to analyze the risk factors affecting COPD. Results A total of 1722 cases were investigated in this study. The prevalence of COPD in people over 60 years old was 13.47%. The average age and body mass index of all research subjects were 70.4±7.5 years old and 20.4±3.5kg/m2, respectively. Among them, 49.25% were males, 20.96% had college degree or above, and 63.88% lived in cities and towns. 23.11% of the subjects still smoked, 32.58% had quit smoking, and 28.16% had a history of passive smoking or were still receiving passive smoking. 16.20% of the subjects had an occupational exposure to dust and particulate matter as coal miners and painters. 51.34% of the subjects had a family history of respiratory diseases. 83.57% of the subjects had other chronic diseases, including coronary heart disease, hypertension, and diabetes. There were 232 cases diagnosed as COPD in this study. All subjects were divided into the COPD group and control group according to the diagnostic criteria of COPD. There were no significant differences between the two groups in body mass index, marital status, education, residence, type of fuel used and family history of respiratory diseases. However, there were significant differences in age, gender, smoking status, occupational dust exposure and chronic disease complications between the two groups. Multivariate logistic regression analysis showed that age (OR70~79 vs. 60~69=2.578, P=0.024; OR≥80 vs. 60~69=4.258, P=0.018), smoking status (ORpassive smoking vs. Active smoking=0.683, P=0.073; ORquit smoking vs. active smoking=0.365, P=0.020; ORNon-smoking vs. active smoking=0.252, P=0.008) and occupational dust exposure (OR=0.158, P=0.010) were the major risk factors for COPD. Conclusion Advanced age, active or passive smoking and occupational dust exposure are important risk factors for COPD.
ABSTRACT
Objective:To observe the clinical efficacy and safety of alteplase combined with butylphthalide in the patients with a-cute ischemic stroke. Methods:Totally 108 cases of acute ischemic stroke patients in our hospital were selected and randomly divided into the experimental group and the control group with 54 ones in each. The two groups were both given such treatments as blood sugar control, blood lipid control, blood pressure control and the other conventional treatment, and the control group was given alteplase for thrombolysis treatment additionally, while the experimental group was given butylphthalide sodium chloride injection combined with al-teplase additionally. Both groups were treated for 14 days. The clinical effect, NIHSS score, daily life ability score and the adverse re-actions in the two groups were observed and compared. Results: The total effective rate in the experimental group was 94. 4%, and that was 81. 5% in the control group, and the difference was statistically significant (P<0. 05). The NIHSS score was reduced signifi-cantly(P<0. 05),and the life ability based on Barthel index score increased significantly (P<0. 05) in the two group after the 7-and 14-day treatment,and the improvement of the experimental group was significantly better than that of the control group with statistically significant differences (P<0. 05). There was no significant difference in the incidence of cerebral hemorrhage and the total adverse re-actions between the groups (P > 0.05). Conclusion: In the treatment of acute ischemic stroke, alteplase combined with bu-tylphthalide is safe and effective, and can effectively improve the neurological function and the ability of daily life, which is worthy of clinical application.
ABSTRACT
Objective:To study the difference in anti-hepatic fiborsis components between pre-and post-processed Trionyx Sinensis Carapace to guide the clinical application of Trionyx Sinensis Carapace. Methods:SDS-PAGE gel electrophoresis was used to compare the constituents in pre-and post-processed Trionyx Sinensis Carapace, and the inhibitory effect on the proliferation of HSC-T6 was deter-mined by MTT. Results:The processed Trionyx Sinensis Carapace had much more components than the crude Trionyx Sinensis Cara-pace,and the relative molecular mass in the first-level band decreased resulting in the generation of micromolecular polypeptides. Both pre-and post-processed Trionyx Sinensis Carapace had anti-hepatic fibrosis, while the vinegar-processed Trionyx Sinensis was more ef-fective. Conclusion:The difference in the active components in pre- and post-processed Trionyx Sinensis Carapace is obvious, which provides foundation for the clinical application and further researches.
ABSTRACT
Objective:To observe the clinical efficacy and safety of alteplase combined with butylphthalide in the patients with a-cute ischemic stroke. Methods:Totally 108 cases of acute ischemic stroke patients in our hospital were selected and randomly divided into the experimental group and the control group with 54 ones in each. The two groups were both given such treatments as blood sugar control, blood lipid control, blood pressure control and the other conventional treatment, and the control group was given alteplase for thrombolysis treatment additionally, while the experimental group was given butylphthalide sodium chloride injection combined with al-teplase additionally. Both groups were treated for 14 days. The clinical effect, NIHSS score, daily life ability score and the adverse re-actions in the two groups were observed and compared. Results: The total effective rate in the experimental group was 94. 4%, and that was 81. 5% in the control group, and the difference was statistically significant (P<0. 05). The NIHSS score was reduced signifi-cantly(P<0. 05),and the life ability based on Barthel index score increased significantly (P<0. 05) in the two group after the 7-and 14-day treatment,and the improvement of the experimental group was significantly better than that of the control group with statistically significant differences (P<0. 05). There was no significant difference in the incidence of cerebral hemorrhage and the total adverse re-actions between the groups (P > 0.05). Conclusion: In the treatment of acute ischemic stroke, alteplase combined with bu-tylphthalide is safe and effective, and can effectively improve the neurological function and the ability of daily life, which is worthy of clinical application.