ABSTRACT
Objective To investigate the genetic characteristics and prognostic influencing factors of the middleˉhighˉrisk patients with multiple myeloma (MM) based on Mayo Stratification of Myeloma and RiskˉAdapted Therapy (mSMART) consensus guidelines. Methods A total of 179 hospitalized MM patients in Fujian Provincial Hospital from June 2009 to October 2017 were collected. Eventually, 49 patients were included except for the patients who were unable to perform mSMART stratification. According to the mSMART stratification criteria, the patients were divided into lowˉrisk group (24 cases) and middleˉhighˉrisk group (25 cases). The genetic characteristics of the two groups were analyzed to explore the relationship between mSMART stratification and clinical features. KaplanˉMeier method and logˉrank test were used to make survival analysis; logistic regression analysis was used to analyze the prognostic influencing factors in highˉrisk patients. Results The incidence of CSK1B gene amplification was the highest in the lowˉrisk group (41.7%, 10/24), while in the middleˉhighˉrisk group, the incidence of RB1 gene deletion was the highest (88.0%, 22/25). In the lowˉrisk group and the middleˉhighˉrisk group, there were no statistical differences in bone destruction, hypercalcemia, renal damage, anemia, β2 microglobulin abnormality, albumin abnormality, lactate dehydrogenase abnormality, and plasma cell ratio abnormality (all P> 0.05). Survival analysis showed that the median survival time of the middleˉhighˉrisk group was lower than that of the lowˉrisk group (23.19 months vs. 39.71 months, P＝ 0.043). Multivariate logistic regression analysis found that anemia and bone destruction were risk prognostic influencing factors for mSMART stratification as a middleˉhighˉrisk group (P＝ 0.044, P＝ 0.002). Conclusion mSMART stratification could indicate the poor prognosis for the patients with middleˉhighˉrisk, and the anemia and bone destruction are risk prognostic influencing factors for patients with middleˉhighˉrisk stratification.
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Objective To investigate the association between multiple single nucleotide polymorphisms (SNP) with esophageal and gastric cancer,and to search the shared genetic risk loci for esophageal and gastric cancer in Han population of Henan Province.Methods Five hundreds cases of esophageal cancer,600 cases of gastric cancer and 600 persons undergoing physical examination in the Henan Provincial Tumor Hospital were selected.Seven SNP loci were selected.The genotyping was performed by adopting the Sequenom MassAR-RAY SNP genoting technique.The relative odds ratios(OR) and 95 ％ confidence intervals(CI) were calculated by unconditional logistic regression.Results In allelic model,the two SNP loci were correlated with the risk of esophageal cancer,which were rs4785204 (OR =1.43,95 ％ CI:1.12-1.85,P =0.01) and rs4924935 (OR =0.76,95 ％CI:0.61-0.99,P=0.04).The four SNP loci were correlated with the risk of gastric cancer,gastric cancer,which were rs13361707(OR=1.23,95％CI:1.13-1.56,P=0.00),rs4779584(OR=1.25,95％CI:1.11-1.58,P=0.04),rs4785204(OR=1.24,95％CI:1.03-1.49,P=0.03)and rs4924935(OR=0.76,95％ CI:0.60-0.99,P =0.04).In the genetic model analysis,the four loci were significantly correlated with the risk of esophageal cancer,which were rs6687758,rs401681,rs4785204 and rs4924935(P＜0.05);the three loci were correlated with the gastric cancer,which were rs13361707,rs4779584 and rs4785204(P＜0.05).Conclusion Multiple SNP loci have the relationship with the risk of esophageal and gastric cancer in Han population of Henan Province.The genetic variation of rs4785204 and rs4924935 loci may simultaneously play an important role in the occurrence and development of esophageal and gastric cancer.
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This article is based on the observation of the temporomandibular joint(TMJ) and on the analysis of its morphological structure. The normal values of 15 items, used to represent the structure of the joint, have been established.Three indices, that is the glenoid fossa index, the articular tubercle index and the condyle index, are accepted to express the geometrical characters and to reflect the close relationship between the two functional parts of the joint. Besides, the frequency distributing curves are presented. It is concluded that the male's TMJ is eminently larger than the female's, while there is no distinct difference between left and right sides and between groups with or without occlusion. This result might meet the needs of the Clinical research as well as the design of the artificial TMJ.