[Henoch Schonlein nephrites in children: clinical features and outcome: about 34 cases]

To describe epidemiological, clinical, histological aspects, treatment and outcome of Henoch-Sch"nlein nephrits in children. A retrospective study was conducted on medical data of 34 patients with Henoch-Sch"nlein nephritis From January 1, 1996 to December 31, 2010 in the Pediatric Department of Charles Nicolle Hospital. Nephritis occured in 68,7%. The average patient age was 7 years 2 months and sex ratio was 0,6. Microscopic hematuria was noted in 23,5%, moderate proteinuria with or without hematuria was observed in 20,5%. Nephrotic syndrome was noted in 29,5%; nephritic syndrome was associated to nephritic syndrome in 23,5%. Isolated hypertension was noted in one patient. Follow-up was 2 years 6 months. Remission was noted in 26 cases [76,4%], minor urinary abnormalities in 7 cases [20,5%] and renal active disease in one case. Relapse was observed in 6 cases. Our study was characterized by the predominance of severe renal manifestations and low grade histological aspects as well as favourable outcome in most 90% of cases

[Predictive factors of severe henoch-schonlein nephritis in children: About 34 cases]

Henoch Schonlein Purpura is the most frequent vasculitis in children. Renal involvement is variable. Renal manifestations vary from isolated microscopic hematuria to the association on nephrotic syndrome to nephritic syndrome. To determine the predictors of severe Henoch - Schönlein nephritis. Retrospective study over 15 years [1996-2010] of 34 chidren, with henoch-schonlein nephritis. Renal involvement was determined in 68.7%. Mean age was 7.23 years [3-14 years]. Renal manifestations were variable. Moderate renal manifestations were noted in 15 cases. Microscopic hematuria was observed in 23.5% of cases and moderate proteinuria with or without hematuria is noted in 20.5% of cases. Severe nephritis was noted in 18 cases: nephrotic syndrome in 29.5% and nephrotic syndrome associated to nephritic syndrome in 23.5%. Hypertension without urinary anomalies was observed in one case. In univariate analysis, factor predictive of severe nephritis were: male sex, macroscopic hematuria, biologic inflammatory syndrome and leukocytosis. In multivariate analysis, only the leukocytosis was predictor of severity. In our study, only leukocytosis was predictor of severity in henoch-schönlein nephritis