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Objective To optimize the manufacture process for Zhibai Anshen oral liquid. Methods The orthogonal designed experiments were conducted to monitor the effects of three factors on the content of mangiferin. The three factors included the amount of water, extraction time and alcohol precipitation concentration. Six month accelerated stability study and twelve month long term stability study were performed. Results Optimum percolation process was boiling the mixture with 10 times of water for 1 hour, followed by deposition with 60% alcohol. Conclusion This optimized process can be used for mass production.
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Objective To compare the differences in plantar kinetics between older male adults and young male adults during walking, and to explore the influences of aging on plantar kinetics. Methods The in-shoe plantar sensory measurement system was used to collect and compare left foot parameters of 13 older men and 14 young men during tandem walk, including contact time, beginning of contact in percentage of roll over process (%ROP), and end of contact in %ROP, peak pressure, instant of peak pressure in %ROP, maximum mean pressure, pressure-time integral, maximum force, instant of maximum force in %ROP, mean force and force-time integral. Results Beside media arch, the contact time on all regions of older men was longer, whereas, the beginning of contact in %ROP on lateral heel, lateral arch was greater, and the end of contact in %ROP on medial heel and 2nd-3rd metatarsal head was smaller compared with young men. The maximum force and mean force on the whole foot region, and the maximum mean pressure and maximum force on 2nd-3rd metatarsal head of older people were significantly lower; the pressure-time integral on the whole foot region, the 4th-5th metatarsal head, the 2nd -5th toes, and the force-time integral on the whole foot region, medial heel, lateral heel and 2nd -5th toes were significantly higher compared with young men. Conclusions During tandem walking, plantar fascia dysfunction might be one of the main reasons for the decline of postural control ability, and the contraction enhancement of flexor digitorum longus and flexor digitorum brevis could compensate for postural stability improvement in older men.
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Objective:To understand the status of psychological capital and disaster preparedness of clinical nurses and analyze the relationship between them.Methods:From August to October 2020, 508 clinical nurses were selected from 8 Class Ⅲ hospitals in Zhejiang province by convenience sampling method. General information questionnaire, nurses' psychological capital questionnaire and disaster preparedness questionnaire were used. A total of 508 questionnaires were sent out and 503 valid questionnaires were collected with an effective rate of 99.01%.Results:The total score of disaster preparedness score of 503 clinical nurses was (179.53±41.11) points, mean items score was (3.99±0.91) points, psychological capital was (91.86±14.68) points, mean items score was (4.49±0.73) points. Correlation analysis showed that nurses' psychological capital was positively correlated with disaster preparedness ( r value was 0.610, P<0.05). Regression analysis showed that psychological capital, department, working years, whether participated in disaster training and disaster event rescue had significant impact on disaster preparedness of clinical nurses ( t values were 2.002-16.770, P<0.01 or 0.05). Conclusions:The knowledge, skills and post disaster management of clinical nurses are still deficient. Psychological capital affects the level of disaster preparedness of nurses to a certain extent. Nursing managers should formulate targeted intervention measures to enhance the level of psychological capital of nurses, so as to better improve the disaster preparedness of clinical nurses.
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Objective To compare the differences in long-term jogging and Tai Chi in terms of neuromuscular latency and time to peak of surface electromyography (EMG) in older males during lateral sudden perturbation. In addition, an effective means to enhance neuromuscular response and muscle contraction efficiency of older males during lateral postural challenges was investigated. Methods Postural reactions of young males, older sedentary male controls (without regular exercises), older male joggers (with long-term jogging practice), and older male Tai Chi participants (with long-term Tai Chi practice) were evoked by means of a sudden unpredictable lateral translation platform. Surface EMG signals of peroneus longus, anterior tibialis, gluteus medius, and erector spinae were collected by an EMG detection and analysis system. Results The latencies of peroneus longus, anterior tibialis, and gluteus medius were delayed in the older sedentary male controls compared with those in young males. The neuromuscular reactions of anterior tibialis and erector spinae in older Tai Chi male participants were faster than those of older sedentary male controls. The contraction speeds of peroneus longus, anterior tibialis, and gluteus medius in young males were higher than those in three older groups during sudden lateral perturbations. Conclusions Long-term Tai Chi practice can enhance the responses of ankle and trunk muscles of older males during lateral postural challenges, but it has little effect on the muscle contraction efficiency of older males.
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The paper described the development stages of a hospital performance evaluation scale based on patient experience.An empirical application on 7 856 patients of 26 hospitals in four provinces in the country identified the challenges encountered in the course of its application.These include limits of patients experience,variations on the experience reports incurred by different services experienced by patients,and setting of the patient-inpatient ratio among others.Solutions proposed based on these studies aim at creating a patient experience scale tailored to Chinese patients.
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Objective To study the clinical efficacy of the combination of sephedex and docetaxel used in transcatheter arterial chemoembolization (TACE) for clinical treatment of primary liver cancer.Methods 120 patients with primary liver cancer in our hospital were divided into the experimental group and the control group randomly and equally, the 60 cases in experimental group were treated with sephedex suspensoid (Sephedex, G-50, 300-500 μm) and docetaxel-iodized oil, while other 60 cases in control group were treated with docetaxel-iodized oil suspension liquid.Results The success rate of surgical intubation in the two groups was 100%.After an average follow-up of 12 months, the postoperative tumor diameter of the experimental group was reduced by (4.4±1.4) cm, while that of the control group was (1.8±1.0) cm;The overall response rate was 70% in the experimental group in contrast to 30% in the control group;the alpha fetal protein (AFP) value was decreased by (33.2±15.2) μg/L in the experimental group and (10.4±9.8) μg/L in the control group.Conclusion The combination of sephedex, docetaxel suspensoid and iodized oil shows great potential in TACE treatment of primary liver cancer, from which the treatment effect can be improved significantly.
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Objective To explore the apoptosis effect of docetaxel combined gamma knife on hepatoma cell SMMC-7721 subcutaneous xenograft in nude mice.Methods Subcutaneous xenogyaft models were constructed and were divided into two groups:control group and experimental group.The experimental group was treated with docetaxel 60ug/0.3ml once every 3 days for 6 times and gamma irradiation once every other day for 6 times (with indoor temperature of 137Cs radiation source irradiating the tumor and of fractionated schedule 5Gy with the total dose of 10Gy every time).The control group was treated with physiological saline with the same dose of 60 ug/0.3 mL.Tumor growth was observed.Tumor samples were cut 30 days after the treatment and TUNEL was used to detect the apoptosis of tumor cells.Results Tumor growth rate in experimental group significantly slowed down.Apoptotic index in experimental groups was significantly higher than that in control group (P ＜ 0.05) Cornclusion Docetaxel combined gamma knife can inhibit the growth of hepatocellular carcinoma in nude mice.
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Objective To study the fingerprint of Polygonum cuspidatum from various regions by HPLC and provide technical support for the identification.Methods HPLC conditions :the chromatographic column was Agilent ZORBAX SB-C18 (4.6 mm × 250 mm,5 μm);the mobile phase was 0.1% formic acid in water and acetonitrile (A-B);gradient elution ;the de-tection wavelength was 306 nm ;the flow rate was 1 ml/min;the column temperature was 30 ℃ ;injection volume was 20 μl. Results The HPLC gradient conditions could effectively separate polydatin,resveratrol,emodin and emodin ether,etc.Con-clusion This method is stable,effective and durable,which is instructive to the herbs data identification of Polygonum cuspi-datum.
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This study aimed at comparing the United States, Britain, Australia, the Netherlands and China’s national performance evaluation, and sum up the experience to provide a theoretical basis for the China’s development of hospital performance evaluation system. The study found that China needs to consider the patient's perspective, to establish a fixed third-party performance evaluation agencies, establish an effective incentive mechanism and feedback mechanism and combine a variety of assessment methods in the development of hospital performance evaluation index system.
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OBJECTIVE@#To investigate the efficacy of the treatment of endoscopic sinus surgery on patients dignosed as chronic sinusitis with nasal polyps(CRSwNP) complicated and asthma.@*METHOD@#Data of 45 patients with CRSwNP complicated asthma were analyzed retrospectively.@*RESULT@#All cases were followed up for a period of 1 to 3 years after operation. In the 45 cases treated with ESS, 32 cases were cured, 9 cases were improved and 4 cases were inefficient by the treatment. The cure rate was 91.1% (41/45). The asthma symptoms were improved in 16 patients compared to 4 before the surgery.@*CONCLUSION@#With ESS based on combined therapy,it can significantly improve the condition of CRSwNP, asthma symptoms and pulmonary function. Meanwhile, sufficient perioperative period preparation should be made to ensure the safety of the operation.
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Humans , Asthma , Chronic Disease , Endoscopy , Nasal Polyps , Nasal Surgical Procedures , Paranasal Sinuses , General Surgery , Retrospective Studies , Sinusitis , General SurgeryABSTRACT
OBJECTIVE@#To investigate the therapeutic effect of revision endoscopic sinus surgery for recurrent chronic rhinosinusitis.@*METHOD@#Clinical data of 45 cases of recurrent rhinosinusitis treated in our hospital were retrospectively analyzed. Revision endoscopic sinus surgery was performed in all the patients.@*RESULT@#All the patients were followed up for a period of 1 to 2 years after operation. No serious complication occured. The cure rate was 75.6% (34 cases), 8 cases (17.8%) improved, while other 3 cases (6.6%) were of no effect.@*CONCLUSION@#Recurrent rhinosinusitis is closely related with medical treatment before the surgery, adhesion in nasal cavity after the surgery, deviation of nasal septum, treatment of superior turbine and inferior turbine and regular medicament management after the surgery. Revision endoscopic sinus surgery is an effective method for recurrent recurrent rhinosinusitis. The efficacy of revision endoscopic sinus surgery can be greatly improved by reasonable perioperative management, skilled operation and regular follow-up postoperatively.
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Humans , Chronic Disease , Endoscopy , Methods , Follow-Up Studies , Paranasal Sinuses , General Surgery , Reoperation , Retrospective Studies , Rhinitis , General Surgery , Sinusitis , General SurgeryABSTRACT
OBJECTIVE@#To investigate the clinical features, therapeutic methods and therapeutic efficacy of imflammatory myofibroblastic tumor(IMT)of the nasal cavity and paranasal sinuses.@*METHOD@#Clinical data of 14 cases diagnosed as IMT by pathology were retrospectively analyzed. There were 8 males and 6 females,age ranging from 18 to 77 years. 12 cases of them were treated by surgery while 2 cases received postoperative radiotherapy.@*RESULT@#All cases were operated. All the patients were followed up for a period of 1 to 7 years after operation and two cases were proved low grade IMT pathologically. Eight cases survived with no recurrence until the last follow-up and 6 cases relapsed, of which 4 cases died and 2 were alive with tumor.@*CONCLUSION@#IMT of the nasal cavity and paranasal sinuses is very rare. The diagonosis of IMT is based on pathology and immunohistochemistry. Proper diagnosis is essential to avoid mutilating and disfiguring surgical procedures. Radical excision is still the first choice of treatment for IMT of the nasal cavity and paranasal sinuses. Chemotherapy and radiotherapy may not be helpful to prevent recurrence after operation. Due to high recurrence rate, long-term follow up is necessary after operation.
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Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Immunohistochemistry , Nasal Cavity , Pathology , Neoplasm Recurrence, Local , Neoplasms, Muscle Tissue , Pathology , Radiotherapy , General Surgery , Paranasal Sinus Neoplasms , Pathology , Radiotherapy , General Surgery , Paranasal Sinuses , Pathology , Retrospective StudiesABSTRACT
OBJECTIVE@#To investigate the efficacy of endoscopic nasal cavity expansion surgery on obstructive sleep apnea hypopnea syndrome (OSAHS) and nasal obstruction.@*METHOD@#Clinical data of 48 OSAHS patients with structural abnormality in nasal cavity treated in our department were retrospectively analysed. These patients received endoscopic nasal cavity expansion surgery and were observed for the relief of both subjective and objective symptoms.@*RESULT@#PSG was reexamined 12 months postoperatively. Of all the patients, 29 cases (60.4%) showed complete recovery, 10 cases (20.8%) showed remarkable improvement of the symptoms, 4 cases (8.3%) exhibited curative effect and 5 cases (10.4%) were of no effect, respectively. The symptoms of apnea, hypopnea, LSaO2 and somnolence were significantly improved in all patients,and nasal congestion was obviously relieved. The improvement of snore was not evident.@*CONCLUSION@#Endoscopic nasal cavity expansion surgery is effective and safe for the treatment of OSAHS mainly due to nasal obstruction. Operation should be performed to correct structural abnormality in nasal cavity and adjust symmetric distribution of nasal airflow on both sides in order to maintain normal ventilation function. The procedure is applicable to OSAHS patients accompanied by nasal congestion and upper airway resistance syndrome and personalized adjustment is beneficial for better clinical efficacy according to the condition of different patients.
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Adult , Female , Humans , Male , Middle Aged , Young Adult , Endoscopy , Follow-Up Studies , Nasal Cavity , General Surgery , Nasal Obstruction , Pathology , General Surgery , Retrospective Studies , Sleep Apnea, Obstructive , General Surgery , Treatment OutcomeABSTRACT
OBJECTIVE@#To investigate the diagnosis and treatment of esophageal perforation and neck abscess induced by esophageal foreign body and to make a better solution for the disease.@*METHOD@#Twenty-four cases with esophageal perforation and neck abscess induced by esophageal foreign body treated in our department were surgery under general anesthesia. The foreign bodies were removed via esophagoscope in 14 cases, thorocomy in 3 eral neck incision in 5; and no foreign bodies were found in 2 cases.@*RESULT@#There were 16 cases complicated by abscess. Among these complications,there were 10 cases of periesophageal abscess,4 cases of neck abscess and 1 case of mediastinal abscess. In 24 patients, 21 cases cured and one died. One case was sent to the department of endocrinology because of hyperglycaemia and two cases were sent to the department of thoracic surgery for further treatment.@*CONCLUSION@#Early diagnosis and treatment is the key to the management of esophageal perforation induced by esophageal foreign body. Thin-section CT has a high value for the diagnosis and differential diagnosis in such patients. Once deep neck abscess is diagnosed, an early abscess surgical drainage, an appropriate antibiotics and a nutrition supporting treatment are effective for the patients.
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Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Abscess , General Surgery , Diagnosis, Differential , Drainage , Esophageal Perforation , General Surgery , Esophagus , Foreign Bodies , General Surgery , Neck , PathologyABSTRACT
OBJECTIVE@#To explore and discuss the characteristics of benign fibro-osseous lesion of naso-sinuses and the features and indications of different surgical choice with endoscope.@*METHOD@#Fourteen patients with benign fibro-osseous lesion of naso-sinuses were treated through endoscopic surgery, of which 9 cases underwent endonasal endoscopic surgery simply, 2 cases were operated with a superciliary arch incision through endoscope, 1 case underwent endoscopic caldwell-luc' surgery, 1 case was operated with endoscopic surgery through frontal recess of tears, and 1 case was operated with Draf II surgery under endoscope.@*RESULT@#In all of patients, 2 cases relapsed, 2 cases had residual lesions, 4 cases had complications including numbness and scar of incision, no relapse and no complications in other 6 cases.@*CONCLUSION@#Endoscopic resection of benign fibro-osseous lesion of naso-sinuses with different surgical choice was of special advantages, but the exactly indications, relapse rate and complications should be observed and reckoned deeply.
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Humans , Cicatrix , Endoscopes , Endoscopy , Frontal Bone , Frontal Sinus , Neoplasm Recurrence, Local , Paranasal Sinus Neoplasms , General SurgeryABSTRACT
OBJECTIVE@#To investigate the clinopathological characteristics, differential diagnosis, therapy and prognosis of sinonasal mucosal malignant melanoma.@*METHOD@#Clinopathological data of 18 cases which were diagnosed by pathology and immmunohistochemistry were analyzed retrospectively. All cases were proved by pathology and immmunohistochemistry. All cases were performed operations. 5 underwent single surgery. 4 underwent surgery plus adjuvant radiotherapy. 4 underwent surgery plus adjuvant radiotherapy chemotherapy. 5 underwent surgery plus adjuvant chemoradiation.@*RESULT@#All cases were followed up for a period of 1 to 7 years after operation. Twelve patients died of tumor until the last follow-up, meanwhile 6 patients stayed alive. In Six cases recurrence occurred. In five casescervical lymph node metastasis occurred, of which 3 cases received neck dissection and 2 cases received chemotherapy and radiotherapy due to no surgical indications. In three cases distant metastasis oc- curred.@*CONCLUSION@#Sinonasal mucosal malignant melanoma is rare and highly heterogenous. Current diagnosis depends on clinical characteristics and immunohistochemical examination. It still should be differentially diagnosed from other tumors. CT and MRI image examination can provide some helpful information to understand the extent and nature of lesions. The treatment of nasal endoscopic or the surgery under endoscopy has become to be a safe, viable and reasonable alternative to open resection. Appropriate indication must be carefully selected for these lesions.
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Humans , Chemotherapy, Adjuvant , Endoscopy , Lymphatic Metastasis , Melanoma , Drug Therapy , Pathology , General Surgery , Mucous Membrane , Neck Dissection , Neoplasm Recurrence, Local , Nose Neoplasms , Paranasal Sinus Neoplasms , Drug Therapy , Pathology , General Surgery , Prognosis , Radiotherapy, Adjuvant , Retrospective StudiesABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical features, therapeutic methods and therapeutic effects of sinonasal hemangiopericytoma.</p><p><b>METHODS</b>Clinical data of 6 patients with sinonasal hemangiopericytoma, diagnosed by pathology and immunohistochemistry between January 1990 and December 2012 were analyzed retrospectively. There were 4 males and 2 females, with a median age of 58 years. Clinical manifestation included epistaxis and nasal obstruction. These patients were operated on by nasal endoscopic surgery or endoscope-assisted surgery, of which 2 cases of tumor located in the nasal cavity underwent nasal endoscopic surgery and 4 cases of tumor located in the nasal cavity and sinuses underwent endoscope-assisted surgery.</p><p><b>RESULTS</b>All the patients were followed up for a period of 6 months to 7 years after operation. Two cases recurred and 4 cases didn't recurred. One case recurred 6 months after operation and underwent second operation, with no recurrence by further one year follow-up. Another case recurred 17 months after operation and underwent second operation, with recurrence by further 9 months follow-up. This patient lived with tumor over two years.</p><p><b>CONCLUSIONS</b>Hemangiopericytomas are rarely found in the sinonasal cavity. Nasal endoscopic or endoscope-assisted surgery provides satisfactory effect.</p>
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Hemangiopericytoma , Diagnosis , Therapeutics , Nasal Cavity , Nose Neoplasms , Diagnosis , Therapeutics , Paranasal Sinus Neoplasms , Diagnosis , Therapeutics , Prognosis , Retrospective StudiesABSTRACT
OBJECTIVE@#To investigate the diagnostic and therapeutic methods of orbital apex syndrome caused by sinus diseases and to achieve earlier diagnosis and timely treatment.@*METHOD@#Clinical data of 6 cases in our department from January 2008 to March 2012 were retrospectively analyzed.@*RESULT@#All cases had surgical treatment. All cases were preoperatively diagnosed by CT, MRI or intranasal endoscopy. The postoperative pathology showed 2 cases with fungal sphenoiditis, 2 cases with ethmoid mucocele and 2 cases with sphenoid mucocele.@*CONCLUSION@#Orbital apex syndrome caused by sinus diseases is very rare. The possible causes of misdiagnosis are low incidence of the disease, nonspecific eye symptoms, and unawareness of the doctor, especially ophthalmologist. CT, MRI or intranasal endoscopy can greatly improve the diagnosis of the disease. Endoscopic sinus surgery is a safe and effective method for orbital apex syndrome caused by sinus diseases,which is the primary therapy for the disease.
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Adult , Aged , Female , Humans , Male , Middle Aged , Orbital Diseases , Diagnosis , Therapeutics , Paranasal Sinus Diseases , Diagnosis , Therapeutics , Retrospective Studies , SyndromeABSTRACT
OBJECTIVE@#To investigate the diagnosis and treatment of deep neck infection.@*METHOD@#Clinical data of 45 cases treated in our department from Jan 2003 to Apr 2012 were retrospectively analysed.@*RESULT@#Nineteen cases of deep neck infection in 45 patients without abscess formation were treated with high-dose antibiotics. Performed computed tomography, the other 26 patients were treated by abscess incision and drainage, the wound healed well without complications.@*CONCLUSION@#Early diagnosis and treatment of deep neck infection is very important. Once deep neck abscess is diagnosed, early abscess surgical drainage, appropriate antibiotics and nutrition supporting treatment are effective for deep neck abscess.
Subject(s)
Adolescent , Adult , Aged , Child , Child, Preschool , Female , Humans , Male , Middle Aged , Young Adult , Abscess , Diagnostic Imaging , Therapeutics , Anti-Bacterial Agents , Therapeutic Uses , Bacterial Infections , Diagnostic Imaging , Therapeutics , Drainage , Neck , Microbiology , Pathology , Radiography , Retrospective StudiesABSTRACT
OBJECTIVE@#To investigate the efficacy of nasal mucosa contact point headache with the treatment of endoscopic sinus surgery.@*METHOD@#Clinical data of 75 cases with nasal mucosa contact point headache treated in our department from Jan 2008 to Nov 2011 were retrospectively analyzed. These patients were performed with endoscopic sinus surgery.@*RESULT@#All patients were followed up for more than six months. They all achieved significant efficacy and no complications occurred.@*CONCLUSION@#Nasal mucosa contact point headache and primary headache had different clinical features and different treatment. Misdiagnosis were easily made if not being carefully analyzed. Three lines tension relaxing septorhinoplasty combined with nasal bone fracture correction can achieve satisfactory curative effect and can effectively prevent the occurrence of complications. Therefore, it is necessary to strengthen the awareness of this disease. Nasal structure abnormality is the main reason of nasal mucosa contact point headache. The implementation of individualized nasal endoscopic sinus surgery can achieve satisfactory curative effect.