ABSTRACT
Objective To observe the preventive and therapeutic effects of scopolamine tablet and transdermal agent in combination with domperidone for seasickness in different voyage distances and sea state conditions. Methods A total of 236 participants were selected and batched for three trials (Trial 1: 80 sea miles voyage. 1-2 degree of sea state; Trial 2; 80 sea miles voyage. 3-4 degree of sea state; and Trial 3: 200 sea miles voyage. 3-4 degree of sea state). The motion sickness susceptibility questionnaire (MSSQ) was used to assess the seasickness susceptibility. The participants in each trial were divided into comprehensive medication group (CMG) receiving low dose oral and transdermal scopolamine in combination with oral domperidone. prophylactic medication group (PMG) receiving low dose oral and transdermal scopolamine, and placebo control group (PCG) receiving oral vitamine C Motion sickness symptoms were evaluated by using Wiker rating scales. Results In trial 1. the Wiker scores and moderate seasickness incidence in the CMG and FMG were significantly lower than those in the PCG (P0. 05). In trial the Wiker scores were significantly lower in the CMC than in the PCG (P0. 05). In trial 3 the Wiker scores were significantly lower in the CMG than in the PCG (P0. 05). Conclusion low dose oral and transdermal scopolamine in combination with oral domperidone can alleviate seasickness symptoms and decrease incidence of severe seasickness during long-term voyage at sea.
ABSTRACT
Objective: To screen for seasickness behavior parameters in rats with simulated seasickness, so as to investigate the rule of seasickness adaptation in rats. Methods: SD rats were stimulated daily by Crampton model. Urine volume (UV) and amount of fecal particle (FP) were observed during stimulation, and the spontaneous activity (SA) was also determined immediately after stimulation. Interventional experiments were performed using anti-motion sickness drugs to examine the specificity of the indices. Results: On the first day of stimulation, the FP of stimulating group increased significantly compared with the normal control group (P<0.05), while SA decreased significantly (P<0.01). FP and SA of stimulating group gradually recovered with the increase of stimulation period; there was a significant correlation between FP, SA with stimulation times (P<0.01). FP and SA recovered to the normal levels on the 9th, 7th day, respectively. The experimental group received gastric perfusion of scopolamine (0.5, 1 mg/kg) and was then subjected to rotation stimulation. The indices had no significant difference between the experimental group and the normal control group. Conclusion: It is indicated that FP during stimulation and SA after stimulation can be used for effective judgment of seasickness in rats. The rats become adapted to seasickness after 9 days' continuous stimulation.
ABSTRACT
the mood of anger, sadness agitation, having some kind of infection were related to IVT. Case-crossover design seemed to be able to identify the risk factors of IVT and its intensity.