Factors affecting the pregnancy rate in clomiphene citrate treated infertile women

Eighty five out of 165 [51.5%] infertile women treated with clomiphene citrate did not conceive inspite of adequate proven ovulatoty dosage of drug therapy. An effort was made to investigate factor contributing to reduced conception rates. Cervical factor in 25. 9%, male factor in 20% and hyperprolactenemia in 7% were the additional factors picked up on further detailed work up of the couple. Peritubal adhesions in 30.6% women and other additional findings like endometriosis, fibroid uterus and polycystic ovaries could be elicited on diagnostic laparoscopy. Forty five percent couples had one and 28.2% had additional factors responsible for their persisting infertility. Optimal pregnancy rates can be attained if a detailed infertility work up is done and factors other than anovulation are picked up and treated before the clomiphene citrate therapy is started

Clomiphene citrate induced pregnancies and their outcome

Since its introduction in I960, Clomiphcnc Citrate [CO] is probably one of the most widely used medication in infertility practice. In this study one hundred and sixty five patients of interility were treated with CC and 80 [48.5%] conceived. Ninety percent became pregnant within the first 3 cycles of their ovulation confirmed therapy and 60% of them required the minimum standard dose [50 mgx5 days]. Pregnancy wastage was to the extent of 31.3% with the abortion rate of 26.3% following CC therapy and these rates are similar to the figures expected from the infertile population under discussion. Surprisingly the rate of twinning in our study [1.25%] was not different from that reported in the general population [1.6%]. Expectedly the incidence of intervention was high due to preciousness of this pregnancy for obvious reasons

Prognostic value of post coital test in unexplained infertility

Sixty five couples with the diagnosis of unexplained infertility were monitored by post coital test [PCT] for 194 cycles. In each cycle the ovulation timing was determined by length of the menstrual cycle and serial cervical mucus scoring. Post coital test was graded as excellent, good, fair and poor. Pregnancy rate was highest [P 0.01] for cycles with excellent PCT and lowest for cycles graded as poor. Significantly more number of cycles [11.3] were required to achieve pregnancy when PCT was poor compared to when it was excellent [1.5]