ABSTRACT
Predicting the clinical behavior of prostatic carcinoma could be difficult. One approach is to identify the molecular prognostic markers, therefore we evaluate the proliferative rate [MIB-1 antibody] and expression of tumor suppressor gene [P[53] protein] in 30 cases of prostatic adenocarcinoma. Values were correlated with histo-pathological parameters [Gleason score, stage and age of the patients]. Results were compared with the same studies on benign prostatic hyperplasia [n = 2], adenosis [n = 5], prostatic intraepithelial neoplasia [n = 5]. MIB-1 proliferation index was lowest in BPH, followed by adenosis,low grade [PIN], low grade cancer, high grade PIN and high grade cancer. Results of our study showed that MIB-1 proliferation index is highly correlated with tumor grade and clinical stage with percentage 100% and 62.5% respectively. As regard the expression of P[53], our results proved that it was confined to prostatic cancer especially high grades with overall incidence 70%. Also, it was found, that P[53] expression was correlated with tumor grade with incidence [83.3%], clinical stage [87.5%] and patients age> 50ys [75%]. These results provide additional evidence that adenosis is a histological small acinar proliferation more akin to BPH than high-grade PIN or adenocarcinoma.While high grade PIN showed strong correlation with prostatic carcinoma according to cell proliferation. Abbreviations: [PIN] prostatic intraepithelial neoplasm, [BPH], benign prostatic hyperplasia