ABSTRACT
The 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2 methoxybenzamide hydrochloride monohydrate exhibits antiemetic and parasympathomimetic activity. Density () and refractive index (nD) measurements were carried out as a function of drug concentration (c=0.01-0.11 mol·L-1) in aqueous NaCl/LiCl (c=0.05, 0.10 and 0.15 mol·L-1) solutions at 30oC. Linear relation of concentration dependence of density and refractive index were studied. Molar refractivity (RM) of solution was calculated from density and refractive index data and polarizability () was calculated from molar refractivity data. Stronger polarizability effects have been observed with increase in drug concentration.
ABSTRACT
In view of pharmaceutical applications, the density (ρ) and refractive index (nD) of antiemetic metoclopramide hydrochloride monohydrate (MHM) drug in aqueous, aqueous-DMSO and DMSO solutions were measured at 303.15 K in the wide range of concentration of drug. Apparent molar volumes (φv) were calculated from density data and fitted to the Masson relation to determine partial molar volume (φ °v) of drug. Overall, strong drugsolvent interactions with significant structural changes in pure and mixed solvents have been confirmed.