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1.
J Postgrad Med ; 1983 Oct; 29(4): 218-22
Article in English | IMSEAR | ID: sea-116364
3.
Indian J Physiol Pharmacol ; 1982 Jul-Sep; 26(3): 227-30
Article in English | IMSEAR | ID: sea-107056

ABSTRACT

Mn++ produced hypoglycemia in normal rats. The effect was dose-dependent. However, Mn++ did not produce hypoglycemia in alloxan-treated rats. There was a rise in liver glycogen following Mn++ treatment which was correlated with fall in blood sugar at 1 1/2 and 3 hr. There was also increase in the glucose uptake by rat diaphragm upto 47% between 2 and 3 hr. The results suggest that functioning, intact pancreatic beta-cells are necessary for the action of Mn++ and that Mn++ may have a peripheral effect on glucose entry into the cells.


Subject(s)
Animals , Blood Glucose/analysis , Diabetes Mellitus, Experimental/blood , Diaphragm/metabolism , Female , Glucose/metabolism , Hypoglycemia/chemically induced , Liver Glycogen/metabolism , Male , Manganese/pharmacology , Rats
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