Long-Term Intake of Ubiquinol May Improve Cognitive Performance in Community Residents / 日本農村医学会雑誌

Dementia is one of the most serious problems in aging societies. A recent study has reported that higher serum coenzyme Q10 levels could reduce the risk of incident dementia. In this community-based study, we evaluated changes in serum ubiquinol level and cognitive performance following long-term intake of ubiquinol. Sixty-one residents (26 men, 35 women; aged 33-87 years) of Kamijima town in Ehime Prefecture agreed to participate in this study. The participants consumed 100-150 mg ubiquinol per day for 6 months to 2 years. We measured serum ubiquinol level and assessed cognitive performance using the 1-min Digit Symbol Substitution Test (DSST) both at baseline and after long-term ubiquinol intake. We also examined the subjects after a 3-month washout period. At baseline, a strong negative correlation was found between age and DSST score. There was no significant correlation between serum ubiquinol level and DSST score. Following long-term ubiquinol intake, both serum ubiquinol level and DSST score increased significantly. After the 3-month washout period, serum ubiquinol level decreased to almost the baseline level, whereas DSST score did not change significantly. Because this study is a single-arm trial these results should be considered carefully; nonetheless, our findings indicate the probable effects that long-term ubiquinol supplementation improves cognitive performance among community residents.

<b>The Bioavailability of Reduced Coenzyme Q10 Water-Dispersive Powder after Single Oral Administration</b> / 日本補完代替医療学会誌

In this study, we showed the bioavailability of ubiquinol (QH) in the form of water-dispersive powder.Two groups of 5 healthy young subjects received single oral administration of 100 mg of QH in the form of a soft capsule containing QH dissolved in safflower oil or 40% water-dispersive powder in the fasting period, and changes in the plasma QH concentration were monitored over time.The water-dispersive powder form of QH exhibited superior bioavailability even when administered in the fasting period.

Effect of the Reduced Coenzyme Q10 and Exercise Training on the Senescence and Exercise Capacity, Oxidative Stress Regulation System in SAMP1 Mice / 日本補完代替医療学会誌

<b>Objective</b>: We studied the effect of long-term the reduced form of coenzyme Q10 (H₂CoQ10: QH) consumption and exercise training (EX) with SAMP1 mice on senescence, exercise capacity, and an oxidative stress regulation system.<br> <b>Methods</b>: The subjects of this study were 50 SAMP1 mice for accelerated senescence, sorted at random into four groups: one which consumed QH, one which consumed QH and performed EX, one which performed EX, and a control group. The experiment started when the mice were 8 weeks old and the consumption of QH continued for 12 months (12M). The measurement for the oxidative stress regulation system was performed at the start of this study and 12M later. Running time for exercise capacity, senescence grading scores, and body weight were each measured at the start of the study, 6 months (6M) and 12M later. For the oxidative stress regulation system, we used reactive oxygen and free radical analysis equipment, with which we measured plasma oxidative stresses (d-ROM test) and plasma anti-oxidant potential (BAP test), and calculated the ratio of d-ROM to BAP.<br> <b>Result</b>: A combination of QH consumption and EX showed, at a later stage, an inhibiting effect on the increase in senescence grading scores and on the decrease in running time. For the oxidative stress regulation system, the combination showed a decrease in latent anti-oxidant potential caused by the rise of plasma oxidative stresses.<br> <b>Conclusion</b>: Results of this study suggest that a combination of QH consumption and EX is effective in delaying aging, inhibiting the decline of exercise capacity, and decrease in latent anti-oxidant potential.<br>

Effect of the Reduced Coenzyme Q10 and Exercise Training on the Oxidative Stress Regulation System and Exercise Capacity in Mice / 日本補完代替医療学会誌

<b>Objective</b>: We studied the effect of food consumption and exercise training (EX) on the oxidative stress regulation system and exercise capacity in mice.<br> <b>Methods</b>: As subjects of this study, we used 46 male mice, which were classified randomly into four groups: one that consumed the reduced coenzyme Q10 (H₂CoQ10: QH), one that consumed QH and took EX, one that took EX, and a control group. All the groups were set to keep running to their limit on a treadmill for animals. We measured the exercise capacity (running time) of each group at the beginning and after three, six, and nine months of this study. For the oxidative stress regulation system, we used reactive oxygen and free radical analysis equipment at the beginning and 6 months later of this study. We measured plasma oxidative stresses (d-ROM test) and plasma anti-oxidant potential (BAP test) to calculate the ratio of d-ROM to BAP. After nine months of this study we measured plasma anti-oxidants (ANTI-ROM test), values of plasma QH and plasma Q10 to calculate the reduced ratio.<br> <b>Result</b>: As a short-term effect of exercise capacity, prolonged running time were recognized by a combination of QH consumption and EX, and as a long-term effect, prolonged running time was recognized by QH consumption. For the oxidative stress regulation system, d-ROM test and ANTI-ROM test did not show any effect of QH consumption or combination of QH consumption and EX. However an elevated value was indicated in the reduced ratio by a combination of QH consumption and EX.<br> <b>Conclusion</b>: This study has revealed that a combination of QH consumption and EX has an effect on exercise capacity and the oxidative stress regulation system such as reduced ratio.<br>

A Successfully Treated Ruptured Aneurysm in a Patient over 90 Years of Age using early Rehabilitation and a One-way Ball Valve for Ventricular Drainage / The Japanese Journal of Rehabilitation Medicine

We report a case of a ruptured aneurysm in a patient in her 90's who was treated by coil embolization and returned to her independent life after discharge. A 95-year-old woman with a diagnosis of subarachnoid hemorrhage (SAH) of Hunt & Kosnik Grade II was treated by coil embolization, ventricular drainage, and a ventriculo-peritoneal shunt. The ventricular drainage was assembled as a closed system using a newly developed one-way ball valve to regulate the cerebrospinal fluid (CSF) outflow. With this system the patient was able to assume any posture and perform any movement she wished. The patient was freed from the physical constraint involved in conventional ventricular drainage. Early rehabilitation during the ventricular drainage would be useful to prevent pneumonia and muscle atrophy.