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International Journal of Stem Cells ; : 200-208, 2015.
Article in English | WPRIM | ID: wpr-29879

ABSTRACT

BACKGROUND: Atherosclerosis is the leading cause of death worldwide. there are no effective approaches to regressing atherosclerosis due to not fully understood mechanisms. Recently, stem cell-based therapies have held promises to various diseases, including vascular diseases. AIM: The present study aimed at investigating the possible effect of cord blood mesenchymal stem cell (MSC) therapy on atherosclerosis. MATERIAL AND METHODS: Eighty adult male albino rats were divided into control group (I), atherogenic group (II): subjected to high cholesterol fed diet (200~300 mg/kg body weight) for 12 weeks and 1.8 million units of vitamin D / kg of diet for 6 weeks. Stem cell therapy group (III): injected with stem cells in the tail vein following confirmation of atherosclerosis. Histological, Immunohistochemical and morphometric studies were performed were conducted. RESULTS: Atherogenic group (II) showed increased aortic thickness, intimal proliferation, smooth muscle proliferation and migration. Increased area % of collagen fibers, iNOS and vimentin immunoreactions were recorded and proved morphometrically. All findings regressed on stem cell therapy. CONCLUSION: A definite therapeutic effect of mesenchymal stem cells was found on atherosclerosis.


Subject(s)
Adult , Animals , Humans , Male , Rats , Atherosclerosis , Cause of Death , Cholesterol , Collagen , Diet , Fetal Blood , Mesenchymal Stem Cells , Muscle, Smooth , Stem Cells , Tail , Vascular Diseases , Veins , Vimentin , Vitamin D
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