ABSTRACT
Precocious puberty resulting from hypothalamic-pitiutary-gonadal axis activation is increasing problem in children and early institution of therapy for the axis suppression allows the patients to attain target adult heights. The review evaluates and compares the efficacy of the most commonly used two GnRH analogues: leuprolide and triptorelin; and the recent trends in their dosages.
ABSTRACT
Osteogenesis imperfecta (OI) often leads to severe lower limb (LL) deformities due to recurrent fractures that significantly hamper ambulation. We describe our management experience of correction of LL deformities in four children with OI. Medical management consisted of peri and postoperative pamidronate therapy, calcium supplementation and rehabilitative care. Deformities were corrected with multiple osteotomies and intramedullary fixation by titanium elastic nails. At a mean follow-up of 30 months, all children have significantly reduced fracture incidence and have no evidence of recurrence of deformities with improved ambulatory status. We emphasize the importance of combined medical and surgical therapy for these patients.