ABSTRACT
The antibody response after vaccination by reduced regimen of plasma derived hepatitis B vaccine (Hevac B) was studied. The vaccines were 48 medical student, who were seronegative for HBV markers. The vaccination schedule was at 0, 1 and 6 months, whereas the recommended schedule for this vaccine is at 0, 1, 2, 12 months. Anti-HBs and anti-HBc were measured at 1, 2, 7 months after the first dose. The seroconversion rate of anti-HBs were 14.9, 62.2, 84.6% and GMT (geometric mean titer) were 24.3, 128.4, 8037.3 mlU/ml respectively. No serious side effect was recorded. Six vaccines, who were seronegative after the third dose of vaccination, received another additional dose at 1 year after first dose. Blood testing performed 1 month after such booster dose showed seroconversion in 5 of 6 vaccinees.
ABSTRACT
Comparative study of antibody responses and adverse reactions after two different yeast derived hepatitis B vaccine administrations was performed. Subjects were 96 medical students who had seronegative for HBV markers. The first group of 47 students received H-B-Vax II® vaccine (MSD) 10 µg and the second group (49 students) received Engerix-B® vaccine (SKF-RIT) 20 µg. the vaccination schedule was two doses one month apart and a booster dose at sixth month. Antibody responses were measured at 1 month after each injection. The result showed that, seroconversion rate after booster dose was 100% in both groups. Anti-HBs titers after first and second doses showed no significant difference among two groups, but after booster dose the anti-HBs geometric mean titer was 3,070 mIU/ml in the first group and 6,634 mIU/ml in the second group, which showed statistical significance. Minor adverse reactions such as local pain, inflammation, itching, and malaise were found.