Imaging and pathological features of gastrointestinal stromal tumors / 中华肿瘤杂志

<p><b>OBJECTIVE</b>To investigate the imaging features and pathological manifestations of gastrointestinal stromal tumors (GISTs).</p><p><b>METHODS</b>The imaging characteristics and pathological manifestations of 26 surgically treated patients with histologically confirmed GISTs were retrospectively analyzed.</p><p><b>RESULTS</b>The tumors were found to originate from the small bowel (n=10), stomach (n=8), colon (n=6), mesentery (n=1) and omentum (n=1). The imaging and pathological features of GISTs were (1) most of GISTs were well-defined and exophytic (n=19, 73.1% ), which usually compressed the adjacent tissues but no invasion. The tumor diameter ranged from 5.1 to 23.5 cm with a mean diameter of 11.6 +/- 5.9 cm, (2)most tumors had an inhomogenous density or signal intensity due to necrosis(n=21, 80.8%), hemorrhage (n=15, 57.7%) or calcification (n=3, 11.5%) within the tumor, (3) on the CT or MR images, heterogeneous enhancement pattern presented as peripheral or intra-tumor patchy enhancement was common (n=21, 80.8%). Furthermore, enhanced striped vessels were seen in 12 patients. However, homogenous enhancement pattern was rare (n=5, 19.2%), (4) the most common site where GIST metastasized to was the liver (n=7), followed by the peritoneum (n=4), but rarely to lymph nodes, (5) of these 26 patients, spindle-cell type was observed in 69.2% (n=18), epithelioid-cell type in 23.1% (n=6), and mixed cell type in 7.7% (n=2). Immunohistochemical studies showed positive CD117 expression in all of these 26 patients, but positive CD34 expression in only 22 patients.</p><p><b>CONCLUSION</b>Gastrointestinal stromal tumor usually presents as a exophytic, well-defined large tumor, with internal striped vessels, necrosis or hemorrhage within. It usually metastasizes to the liver or the peritoneum but rarely to lymph nodes. Pathologically, most of gastrointestinal stromal tumors consist of spindle-cells, while a small portion of the tumors are composed of epithelioid-cells or mixed ones. Both CT and MRI play an important role in the diagnosis of gastrointestinal stromal tumors.</p>

Correlation of nuclear DNA contents and p53 protein expression with CT image and prognosis of patients with epithelial ovarian tumors / 第二军医大学学报

Objective: To observe the nuclear DNA contents and expression of p53 protein in epithelial ovarian tumors (EOT) and to explore their correlation with CT images and prognosis in EOT patients. Methods: The nuclear DNA contents, expression of p53 protein and CT findings of 88 EOT patients were analyzed. Twenty-six EOT patients were followed up and were divided into AT group (ancuploid, n=19) and DT group (diploid, n=7) according to DNA ploid, and into p53 protein (+) group (n=15) and p53 protein (-) group (n=11) according to expression of p53 protein. The correlation of nuclear DNA content and p53 protein expression with CT findings and prognosis of EOT patients was analyzed. Results: The DNA index, patient number with AT and protein p53 (+) rate were significantly different between patients with their cystic wall thickness ≥ 3 mm and <3 mm, patients with and without cystic wall nodus, and patients with poorly-defined tumor boundary and well-defined tumor boundary in 88 patients with EOT( P<0. 01). The "enhanced degree of tumor parenchyma" in AT group was obviously higher than that in DT group(P<0. 01) , and was similar between protein p53 (+) group and (-) group. The survival periods of patients in DT group and protein p53 (-) group were longer than those in AT group and protein p53 (+) group (P<0.05, P<0.01). The survival periods of 12 patients in AT group with p53 protein (+) expression were all less than 48 months. Conclusion: Nuclear DNA and p53 protein are correlated with CT findings in EOT patients; the prognosis of ovarian carcinoma with aneuploidy and/or p53 protein (+) expression is poor.