Subject(s)
Adenocarcinoma/diagnosis , Adenocarcinoma/pathology , Adenocarcinoma/physiopathology , Adenocarcinoma/surgery , Biopsy , Diagnosis, Differential , Humans , Laryngeal Mucosa/pathology , Magnetic Resonance Imaging , Male , Middle Aged , Neoplasm Grading , Otorhinolaryngologic Surgical Procedures , Palatal Neoplasms/diagnosis , Palatal Neoplasms/pathology , Palatal Neoplasms/physiopathology , Palatal Neoplasms/surgery , Palatal Obturators , Recovery of Function , Tomography, X-Ray ComputedABSTRACT
BACKGROUND: Endothelial cell dysfunction may play a role in the pathobiology of pre-eclampsia and human essential hypertension. Vasodilators and platelet anti-aggregators such as prostacyclin and nitric oxide are produced by endothelial cells. The half-life of prostacyclin and nitric oxide are reduced by superoxide anion, whereas superoxide dismutase antagonizes its action. OBJECTIVES: To estimate the plasma concentrations of nitric oxide and lipid peroxides and those of catalase and superoxide dismutase in patients with pre-eclampsia and essential hypertension. METHODS: Patients of essential hypertension and pre-eclampsia were selected for the study. Nitric oxide and lipid peroxides were estimated in the plasma and anti-oxidants catalase and superoxide dismutase were estimated in the RBC membranes. RESULTS: The ratio between lipid peroxides and nitric oxide was elevated and the activity of superoxide dismutase reduced in patients with pre-eclampsia and uncontrolled essential hypertension. CONCLUSION: These results suggest that oxidants and anti-oxidants are altered in human essential hypertension and pre-eclampsia.
Subject(s)
Adult , Catalase/blood , Female , Humans , Hypertension/blood , Male , Middle Aged , Nitric Oxide/blood , Oxidative Stress , Pre-Eclampsia/blood , Pregnancy , Superoxide Dismutase/blood , Vitamin E/bloodABSTRACT
As a part of a composite programme of rational drug design (RDD), we had synthesized some substituted benzenesulphonyl glutamines and evaluated their inhibitory activities against Ehrlich Ascites Carcinoma (EAC) cell line in Swiss albino mice. Quantitative structure activity relationship (QSAR) studies of these inhibitory activities using Fujita-Ban model as well as Modified Hansch-Fujita model gave excellent correlations (correlation coefficient r = 0.89 and 0.82 respectively). These results could be useful in designing 'lead' compound with potent inhibitory activity on DNA and RNA synthesis and tumour development.