ABSTRACT
Objective To investigate the effects of different doses of oxycodone on postoperative pain and stress response in patients undergoing gynecological laparoscopic surgery. Methods Sixty patients scheduled for gynecological laparoscopy,aging from 18 to 50 years old,of ASA Ⅰ or Ⅱ,were included and randomized into three groups:control group (group C),low dose of oxycodone group (group L),high dose of oxycodone group (group H),20 cases in each group.Pa-tients in group L,H received 0.05,0.1 mg/kg oxycodone respectively while paitents in group C re-ceived saline 5 ml 1 5 min before the end of the surgery.Visual analogue scale(VAS)pain score and RASS score were measured on 1,6,12 and 24 h postoperatively.Glucose and serum cortisol were also measured before the operation and on time points of 6,12 and 24 h after the operation.Adverse effects were recorded too.Results Compared with group C,VAS were significantly lower in group L and H within 1 hour postoperatively.(P <0.05).VAS was significantly lower in group H than that in group C and L at 6 h postoperatively (P <0.05 ).The RASS scores of group L and H were significantly lower than those in group C (P <0.05)at 1 h postoperatively.Blood glucose and serum cortisol of group L and H increased at 6,12 and 24 h after operation (P <0.05).Compared with group C,blood glucose and serum cortisol were significantly lower in group L and group H at 6,12 h after operation (P <0.05).There was no significant difference in the incidence of adverse reactions in each group. Conclusion Oxycodone 0.1 mg/kg injected before the end of gynecological laparoscopic surgery could effectively relieve postoperative pain with less adverse reactions,and decrease postoperation stress re-sponse.
ABSTRACT
Objective To investigate protective effect of dexmedetomidine on cerebral injury in patients undergoing heart valve replacement surgery under cardiopulmonary bypass (CPB) .Methods 60 patients with CPB underwent cardiac valve replacement were randomly divided into observation group and control group ,and respectively given dexmedetomidine and saline ,before CPB (T1) ,aortic opening (T2) ,CPB (T3) and 6 hours after operation (T4) ,then tested jugular bulb oxygen saturation degree (SjvO2 ) , cerebral arteriovenous internal jugular venous oxygen content difference (Ca-jvO2 )and cerebral oxygen extraction rate(ERO2 ) ,and the plasma levels of S-100βprotein and plasma specific enolase (NSE) .Results In T2 ,T3 ,SjvO2 ,PaO2 increased ,Ca-jvO2 ,ERO2 decreased ,in T3 during rewarming ,SjvO2 ,PaO2 of observation group was significantly higher than control group ,Ca-jvO2 ,ERO2 was lower than that in control group ,there were significant difference between two groups (P<0 .05) .In T2 ,T3 ,T4 ,NSE and S-100βprotein concentration of water increased ,but that of observation group was significantly lower than that of control group ,there were significant differences between two groups (P<0 .05) .Conclusion Dexmedetomidine has cerebral protective effect .