ABSTRACT
BACKGROUNDS: It is well known that intimal hyperplasia is one of the most important cause of vascular graft failure in angioplasty, autogenous venous graft and prosthetic bypass graft. Clinical trials of drugs including antiplatelet agents, anticoagulant, corticosteroid, cyclosporine and prostaglandin were not satisfactory in suppressing intimal hyperplasia. Seeding of endothelial cell also have been done for this purpose with some success. There are several reports that endovascular low dose irradiation and external beam irradiation might reduce the amount of proliferative neointima after arterial injury. METHODS: In order to evaluate the effect of external beam irradiation on intimal hyperplasia in grafted vessel, femoral artery autografts using external jugular vein were performed in dogs, and studied the morphological finding under microscope and compared intimal hyperplasia between control and radiated groups. Group I (control) was not irradiated after graft. But experimental groups were irradiated with 6 Mev electron: Group II, 800 cGy on day 1; Group III, 400 cGy on day 1 and day 4 each; and Group IV, 800 cGy on day 4. Radiation efficacy on intimal hyperplasia was histologically assessed by measuring neointimal thickness at the proximal and distal site of grafted vessel at 6 weeks after graft. RESULTS: Mean neointimal thickness in all irradiated groups were significantly lesser than control group (p0.05). CONCLUSION: These data suggest that low dose external beam irradiation might suppress intimal hyperplasia in grafted vessel, but further study will be necessary to determine optimal dose and timing of radiation delivery, and its efficacy in long segment bypass graft.
Subject(s)
Animals , Dogs , Angioplasty , Autografts , Cyclosporine , Endothelial Cells , Femoral Artery , Hyperplasia , Jugular Veins , Neointima , Platelet Aggregation Inhibitors , TransplantsABSTRACT
Chemotherapeutic agents were evaluated for their effect on the development of urinary bladder tumors, induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in female Sprague-Dawley rats. For 16 weeks, 0.05% BBN was administered orally, and then chemotherapeutic agents (adriamycin and cisplatin) were injected intraperitoneally for 12 weeks. In our preliminary experimental series, an experimental bladder tumor model induced by BBN was useful in evaluating the effectiveness of chemotherapeutic agents. Cisplatin appears to be effective in inhibiting precancerous histologic changes and carcinoma in rat urinary bladder mucosa by BBN. However, the effectiveness of adriamycin was inconclusive.
Subject(s)
Animals , Female , Humans , Rats , Carcinogenesis , Cisplatin , Doxorubicin , Injections, Intraperitoneal , Mucous Membrane , Rats, Sprague-Dawley , Urinary Bladder Neoplasms , Urinary BladderABSTRACT
Multicystic dysplastic kidney is the most frequent cause of abdominal mass in the neonate, but its presentation is variable depending on the size of cystic kidney, state of the opposite kidney and associated anomalies. multicystic dysplastic kidney also represents a spectrum of pathology from unilateral multicystic kidney through segmental and focal multicystic dysplasia to bilateral multicystic kidney. Herein we report 5 cases of MCK with different presentation and histology, a bilateral MCK associated with horseshoe kidney, a large MCK with uremia, a focal segmental MCK with contralateral UPJ obstruction, a small focal segmental MCK with contralateral megaureter and a small MCK detected by ultrasonogram for localization of impalpable testis.