ABSTRACT
BACKGROUND AND OBJECTIVES: A large body of evidence from a variety of experimental systems suggests that cyclooxygenase-2 (COX-2) is important in carcinogenesis. This study was to determine whether cyclooxygenase-1 (COX-1) and COX-2 were overexpressed in laryngeal squamous cell carcinoma, and discuss the possible causal role of COX-2 in the laryngeal squamous cell carcinoma formation. MATERIALS AND METHODS: Tissue samples from 21 pateints with laryngeal squamous cell carcinoma were analyzed by immunohistochemical staining. RESULTS: There was an elevation of COX-2 expression in laryngeal squamous cell carcinoma. Normal buccal mucosa biopsies and normal laryngeal epitheliums adjacent to laryngeal cancer showed nondetectable or weak staining for COX-2 protein. There is no difference in the expression of COX -1 in the normal buccal mucosa, normal laryngeal mucosa and laryngeal squamous cell carcinoma. CONCLUSION: There is an overexpression of COX-2, but not COX-1 in laryngeal squamous cell cancer. This may represent a causal role of COX-2 in the formation and proliferation of laryngeal squamous cell carcinoma. There may also be another role of selective COX-2 inhibition for treatment of laryngeal squamous cell carcinoma.
Subject(s)
Biopsy , Carcinogenesis , Carcinoma, Squamous Cell , Cyclooxygenase 1 , Cyclooxygenase 2 , Laryngeal Mucosa , Laryngeal Neoplasms , Mouth Mucosa , Neoplasms, Squamous Cell , Prostaglandin-Endoperoxide SynthasesABSTRACT
Nodular fasciitis is a benign proliferation of myofibroblasts and is the most common tumorlike lesion of fibrous tissue. The lesion may easily be misinterpreted as sarcoma, clinically and histologically. The lesion usually presents as a rapidly growing subcutaneous tumor, most commonly located in the extremities and trunks in young adults. The head and neck region, however, is the most common site in infants and children, but rare in adults. We experienced one rare case of intraparotid nodular fasciitis which was treated with superficial parotidectomy. We report this case with a review of literature.
Subject(s)
Adult , Child , Humans , Infant , Young Adult , Extremities , Fasciitis , Head , Myofibroblasts , Neck , Parotid Gland , SarcomaABSTRACT
Hemangiomas are well known benign tumors that can occur in any sites of the human body. Although it is relatively common to find hemangiomas occurring in the head and neck areas, it rarely occurs in the external auditory canal. We present a case of capillary hemangioma arising from the external auditory canal with extension onto the adjacent outer layer of the tympanic membrane. It was treated with simple excision and myringoplasty. Early recognition may allow for simple excision without myringoplasty.
Subject(s)
Capillaries , Ear Canal , Head , Hemangioma , Hemangioma, Capillary , Human Body , Myringoplasty , Neck , Tympanic MembraneABSTRACT
Dissociated vrtical deviation(DVD) is frequently associated with infantile esotropia. It is hard to find DVD before surgery for esodeviation, and usually found after surgery. We studied the occurrence of DVD in 176 patients who had had horizontal rectus muscle surgery for the correction of infantile esotropia and followed up for 6 months or more. DVD was seen in 78 patients(44.3%), preoperatively in 27 patients(34.6%) and postoperatively in 51 patients(65.4%). Among 51 patients with DVD after surgery, DVD occurred in 24.0% of patients with preoperative angle of esodeviation less than 50 PD and in 44.6% of patients with preoperative angle of esodeviation more than 51 PD(P0.05). Inferior oblique overaction(IOOA) was accompanied with DVD in 71.8% and occurred without DVD in 28.6%. This study revealed postoperative DVD developed more in large angle esotropia such as deviation angle greater than 51 PD, and IOOA was frequently accompanied. The result suggests that in large angle infantile esotropia with mild IOOA and DVD or fundus extorsion we may need the preventive correction of DVD and IOOA.