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Tuberculosis and Respiratory Diseases ; : 517-521, 2005.
Article in Korean | WPRIM | ID: wpr-75627

ABSTRACT

BACKGROUND: The balances of the proteinases and antiproteinases system have been implicated in the pathogenesis of various exudative pleural effusions. The aim of this study was to examine the matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in exudative pleural effusions. METHODS: The study included 33 tuberculous effusions, 17 malignant, and 5 transudates. The pleural levels of MMP-1 and TIMP-1 were determined using a commercially available ELISA assay. RESULTS: The group of tuberculous effusions showed higher pleural MMP-1 levels than the malignant and transudates. The pleural TIMP-1 levels of the tuberculous and malignant effusions were higher than the transudates. CONCLUSION: Elevated pleural MMP-1 and TIMP-1 levels were found in tuberculous effusions.


Subject(s)
Enzyme-Linked Immunosorbent Assay , Exudates and Transudates , Matrix Metalloproteinase 1 , Peptide Hydrolases , Pleural Effusion , Tissue Inhibitor of Metalloproteinase-1
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