ABSTRACT
Introduction: Antiepileptics and antidepressant medications are known for managing neuropathic pain. We aim to compare the effects of pregabalin with low‑dose amitriptyline and gabapentin with low‑dose amitriptyline in managing neuropathic pain in cancer patients undergoing palliative care. Materials and Methods: We conducted our study on 160 cancer patients who were having neuropathic pain and were undergoingpalliative care treatment in our institute. It was a hospital‑based, randomized, tertiary cancer center‑based observational study. After taking approval from the institutional ethics committee and taking written informed consent from patients, the patients were divided into two groups and the effect of medicines on incidence of neuropathic pain was observed; the incidence of burning sensation and the incidence of adverse effects of medications were also analyzed. Statistical analysis was done using paired t‑test and SPSS version 20 software. Results: The onset of relief in pain was earlier in the pregabalin group as compared to the gabapentin group. There was more reduction in a burning sensation in the pregabalin group as compared to the gabapentin group. The incidence of headaches was the same in both groups. Nausea and vomiting were more in the pregabalin group but the overall difference in adverse effects was not statistically significant (P > 0.05) Conclusions: In the management of neuropathic pain in cancer patients who are undergoing palliative care, a combination of pregabalin with amitriptyline was found to be more effective in pain relief than gabapentin with amitriptyline.
ABSTRACT
Introduction: Cancer pain is known to be one of the Most severe pain anyone in life and is the primary reason for discontinuation of treatment.Sphenopalatine ganglion block (SPGB) can be useful in alleviating pain of carcinoma buccal mucosa. The study aims to analyze the effect of transnasal SPGB in pain management of patients suffering from carcinoma buccal mucosa. Materials and Methods: It was a hospital‑based study done on 150 patients with carcinoma buccal mucosa using a prospective cross‑sectional study design. To do statistical analysis, paired t‑test was used having SPSS software. Results: On visual analogue scale, intensity of pain was found to be notably reduced from 7.42±2.02 to 3.45±1.21 (P < 0.0001), after first sitting. Preprocedure and postprocedure morphine requirement were 90.24 ± 30.24 and 60.42 ± 0.93 mg/day (P > 0.05) At the conclusion of study, the results were found to be statistically significant. Conclusion: Transnasal SPGB is beneficial in improving patient compliance and reducing pain scores and morphine requirement in patients suffering from carcinoma buccal mucosa
ABSTRACT
Introduction :Awareness can be defined as the subjective experience of external or internal stimuli. Recent review of reported cases of awareness suggested the absence of volatile agents or intravenous agents during maintenance of anaesthesia 2. Material & Methods:The study was conducted in SMS Medical College and attached hospital, Jaipur after approval from the institutional ethics committee. The present study was conducted in 105 patients 35 in each group of ASA physical status 1 & 2 posted for elective spinal surgery under general anaesthesia, age between 20-50 years, Hospital – based, randomized, double blind, comparative interventional study. The sample size was calculated 35 subjects in each group. Results: In recovery period, the time to reach BIS to 80 was found to be significantly more in Group B compared to Group C and Group A [P<0.001]. When the groups were compared, all the three parameters of recovery (extubation time, response to verbal commands and time for orientation) were found to be significantly longer in Group B. There were no significant difference between the other two groups, i.e. Group Aand Group C (P< 0.001).Propofol Induction and Maintenance dose found to be significantly more in Group C as compared to group B than Group A. (P < 0.001). Total Propofol requirement was significantly more in group C as compared to group B than Group A. (P< 0.001). Conclusion: Perioperative use of both clonidine and magnesium sulphate significantly reduced the requirement of propofol. They were able to attenuate the haemodynamic response to tracheal intubation. Clonidine was associated with bradycardia and hypotension. Magnesium sulphate caused a delay in recovery.