ABSTRACT
El objetivo de este estudio fue determinar la prevalencia del Virus Sincicial Respiratorio (VSR) en pacientes pediátricos con rinitis alérgica (RA). Se incluyeron 56 pacientes mayores de 7 años y menores de 15 años, con diagnóstico de rinitis alérgica a los cuales se les tomo muestras sanguíneas sin anticoagulante, para la obtención de suero. Se determinó IgG anti VSR e IgE total por la técnica de ELISA. Los resultados muestran que 38 (68%) fueron escolares y 18 (32%) adolescentes, 14 (25%) de sexo femenino y 42 (75%) masculinos. Del total de pacientes estudiados, 52 (92,86%) resultaron positivos a la presencia de anticuerpos IgG anti VSR, observándose una prevalencia general significativa, al igual que el grupo control. Se observó mayor prevalencia (69,2%) en los escolares con respecto a los adolescentes, con predominio del sexo masculino. En los pacientes con RA seropositivos al VSR se obtuvo un incremento significativo (346,8±264,7 UL/ml) de IgE con respecto al grupo control sin RA (116,3±89,7 UL/ml). Los resultados evidencian una alta seroprevalencia de VSR en la región, principalmente en edad escolar, esta infección temprana podría ser determinante en la secreción de mediadores que contribuyen en la aparición y severidad de enfermedades respiratorias como rinitis alérgica y asma bronquial. Por lo tanto se concluye que la cuantificación de IgE total puede ser considerada como una prueba de calidad para el diagnóstico y monitoreo de la rinitis alérgica.
The objective of this study was to determine the prevalence of Respiratory Syncytial Virus (RSV) in pediatric patients with allergic rhinitis (AR). We included 56 patients older than 7 years and younger than 15, with clinical diagnosis of allergic rhinitis (AR). Blood samples were taken without anticoagulants, to obtain serum. IgG anti-RSV and total IgE were determined by the ELISA technique. The results showed that 38 (68%) were schoolchildren and 18 (32%) adolescents, 14 (25%) female and 42 (75%). Of the total number of patients studied, 52 (92.86%) were positive for the presence of IgG anti-RSV antibodies, with a significant overall prevalence, similar prevalence presented by the control group. A significant increase (346.8 ± 264.7 UL / ml) of IgE was observed in patients with RA who were seropositive for RSV compared to the control group without RA (116.3 ± 89.7 UL / ml). The results show a high seroprevalence of RSV in the region, especially in school age, this early infection could be determinant in the secretion of mediators that contribute to the appearance and severity of respiratory diseases such as allergic rhinitis and bronchial asthma. Therefore it is concluded that the quantification of total IgE can be considered as a quality test for the diagnosis and monitoring of allergic rhinitis.
ABSTRACT
Las enfermedades exantemáticas son un grupo de patologías causadas por agentes virales, que se presentan frecuentemente sobre todo durante los primeros años de vida y responden en su mayor proporción a infecciones causadas por virus como sarampión, varicela, rubéola y dengue, entre otros. El objetivo de este estudio fue evaluar la inmunidad a los virus de sarampión y varicela en niños y adolescentes, residentes del municipio Páez del estado Zulia, Venezuela. Se estudiaron 174 muestras provenientes de escolares y adolescentes aparentemente sanos, sin distingo de sexo y en un rango de edad comprendido entre 8 a 17 años, las cuales fueron analizadas mediante la técnica de ELISA. Se detectó una frecuencia de 59,7 por ciento para el virus del sarampión y un 44,8 por ciento para varicela. La seroprevalencia para sarampión y varicela estuvo homogéneamente distribuida en todos los grupos etarios. En ambas enfermedades se observó una mayor frecuencia en el sexo masculino, no encontrándose diferencias significativas. Se evidencia una baja inmunidad a estos virus, se sugiere incrementar los programas de vacunación en este municipio para eliminar la circulación de estos agentes infecciosos en la población
Exanthematic diseases are a group of pathologies caused by viral agents, which appear frequently during the first years of life and respond in greater proportion to infections caused by viruses, such as measles, varicella (chickenpox), rubella (German measles) and dengue, among others. The objective of this study is to evaluate immunity to measles and chickenpox viruses in children and adolescents residing in the Páez municipality, state of Zulia, Venezuela. Without regard to sex, 174 samples from apparently healthy adolescents and children between 8 and 17 years old were studied and analyzed using the ELISA technique. A frequency of 59.7 percent was detected for the measles virus and 44.8 percent for varicella. Seroprevalence for measles and varicella was distributed homogeneously in all age groups. For both diseases, greater frequency was observed in males, without significant differences. The study demonstrated low immunity to these viruses and suggests increasing vaccination programs in this municipality to eliminate circulation of these infectious agents in the population
Subject(s)
Humans , Male , Adolescent , Female , Child, Preschool , Child , /pathogenicity , Immunity/physiology , Measles virus/pathogenicityABSTRACT
Background: Dengue infections may affect the liver, causing inflammation and compromising its function. Aim: To determine serum aminotransferases in patients with Dengue. Material and methods: One hundred eighty four patients with Dengue confirmed with anti-Dengue IgG and IgM antibodies measured by ELISA, aged 1 month to 79 years, were studied. As controls, 40 patients with acute hepatitis B virus infection aged 11 to 59 years and 40 healthy individuals, aged 14 to 55 years, were also studied. Alanine and aspartate aminotransferases (ALT and AST) were determined using a colorimetric method. Results: Sixty one percent of patients with Dengue had elevated aminotransferase levels. In patients with Dengue and hepatitis B, mean ALT levels were 21.3±8.4 and 29.7±18.8 U/I, respectively. Mean AST values were 37.3±19, 19.6± 16.4 and 4.3±1.7 U/I in patients with Dengue, hepatitis B and controls, respectively. During the year 2001, there was an increase in the number of cases with hemorrhagic fever caused by Dengue and 65 percent had elevation of aminotransferases. Conclusions: An increase in aminotransf erase levels is common in patients with Dengue.