Screening result analysis of diabetes in high-risk population in Songjiang District of Shanghai, 2016-2017 / 上海预防医学

Objective To investigate the prevalence of diabetes and impaired glucose regulation in high risks community residents in Songjiang District of Shanghai, and to explore the risk factors affecting their blood glucose metabolism, providing effective suggestions for improving community diabetes prevention and treatment. Methods Questionnaire, physical examination and laboratory testing were used to collect information on the basic characteristics and blood glucose levels of 21 035 residents in Songjiang District who were assessed to be at high risk of diabetes. Results A total of 3 008 people with impaired regulation and 2 241 patients with diabetes were detected.The detection rates were 14.3% and 10.6%, respectively.It was found that as the residents′ age was higher, their education level was lower, high-risk factors for them were numerous, and their detection rates of diabetes and impaired sugar regulation were higher.It was found that age, gender, history of impaired glucose regulation, relatives with type 2 diabetes, hypertension, dyslipidemia and overweight/obesity were all factors influencing blood glucose metabolism (P < 0.05). Conclusion Blood glucose screening in high-risk population of diabetes is helpful for the early detection of diabetic patients and those with impaired glucose regulation.It is necessary to strengthen the attention of population at risk of diabetes and take appropriate interventions.

Analysis of diabetes screening in high-risk population in different communities in Shanghai from 2016 to 2017 / 中华疾病控制杂志

Objective To describe the results of screening for high-risk population of diabetes mellitus among community residents in Shanghai from 2016 to 2017 and analyze the characteristics of subjects with impaired glucose regulation or diabetes patients. Methods After the diabetes risk assessment for the residents aged 35 and older in Changning and Songjiang district of Shanghai, physical examination and blood glucose test were conducted for high-risk groups. Results A total number of 33 469 people in the two communities were screened, 4 555 patients with impaired glucose regulation and 3 412 patients with diabetes were detected. The detection rates were 13.6% and 10.2%, respectively. In high-risk population, aging was significantly correlated with the risk of diabetes(males：P<0.001；females：P<0.001) and impaired glucose regulation(males：P<0.001；females：P<0.001). The risk of diabetes in rural males was lower than that in urban males (OR=0.873，95% CI：0.771-0.988), while rural females had a higher risk of impaired glucose regulation than urban females (OR=1.249, 95% CI: 1.131-1.379). Self-reported history of impaired glucose regulation(males：P<0.001；females：P<0.001), family history of type 2 diabetes(males：P<0.001；females：P<0.001), hypertension(males：P<0.001；females：P<0.001), dyslipidemia(males：P<0.001；females：P=0.015), overweight/obesity(males：P<0.001；females：P<0.001), long-term sedentary lifestyle in males (P=0.002) and a history of polycystic ovary syndrome in females (P=0.011) were related to the risk of dysglycemia. The more of the number of high-risk factors for residents, the higher the risk of impaired glucose regulation and diabetes (P<0.001). Conclusions The situation of community diabetes detection and prevention in Shanghai is very serious. Therefore, it is necessary to strengthen the monitoring of high-risk groups of diabetes and take targeted intervention measures to reduce the occurrence of diabetes in high-risk population.

Plasma metabonomic study on the changes of dibutyl phthalate using ~1H NMR / 中国职业医学

OBJECTIVE: To screen small molecule metabolites of dibutyl phthalate( DBP) in the rat plasma using ~1H nuclear magnetic resonance( NMR) technology; and to clarify the changes of metabolites and possible mechanism in metabolic regulation of DBP in rats from the molecular level and the aspects of material and energy metabolism. METHODS: According to random number table method,twenty-four specific pathogen free SD male rats were divided into four groups: control group,low dose group,middle dose group and high dose group with the given dose of 0,500,1 000 and1 500 mg / kg of body mass,respectively. After giving DBP of gavage once a day for two weeks,the plasma samples were obtained,and ~1H NMR spectra was recorded. The plasma metabonomic profiles were analyzed using pattern recognition.Difference metabolites were screened by principal components analysis,partial least squares-discriminate analysis and orthogonal partial least squares-discriminate analysis. Biomarkers was screened by variable importance in the projection norm. RESULTS: There were changes of twelve important metabolites in the plasma metabonomic profiles between DBP treatment groups and control group. The differences of metabolites had dose-effect relationship. Plasma levels of high density lipoprotein cholesterol, low density lipoprotein cholesterol, hydrobutyrate, glycoprotein, citric acid, glucose,creatine phosphate,unsaturated fatty acid,tyrosine and phenylalanine were reduced( P < 0. 05),while lactic acid and pyruvic acid were increased( P < 0. 05). CONCLUSION: DBP induces the metabolic disorders including amino acid metabolism,lipid metabolism and energy metabolism.

Correlationship between chemokines and oxidative stress in chronic hepatitis B / 中华实验和临床病毒学杂志

<p><b>OBJECTIVE</b>The aim of this study is to investigate the possible associations of chemokines IP-10, Rantes and oxidative stress in chronic hepatits B (CHB).</p><p><b>METHODS</b>70 CHB patients and 10 healthy controls were enrolled in the study. Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of IFN-gamma-inducible protein-10 (IP-10) and regulated on activation normal T-cell-expressed and secreted (Rantes) and oxidative stress parameters (glutathione, GSH; glutathione disulfide, GSSG). Correlationship were analyzed by Spearman's rank correlation.</p><p><b>RESULT</b>The levels of IP-10 and Rantes were higher in CHB patients than healthy controls, and strong positive associations were found between IP-10/Rantes and alanine aminotransferase (ALT). The levels of GSH and GSH/GSSG were lower in CHB patients than healthy controls, and GSH and GSH/GSSG were negatively correlated with ALT. The levels of IP-10 and Rantes were negatively correlated with GSH and GSH/GSSG respectively.</p><p><b>CONCLUSION</b>Strong associations were found between chemokines and oxidative stress which participated in the pathogenesis of CHB.</p>