ABSTRACT
Objective To understand the growth and dietary diversity status of children in multi-ethnic areas of Sichuan province,and to explore the associations of dietary diversity with growth and development indicators. Methods Children of 18-36 months old and their primary caregivers were selected with multi-stage cluster random sampling method from rural areas of Han,Tibetan,and Yi ethnic groups in Sichuan province. The sociodemographic information of children and their caregivers was collected using self-designed questionnaire.The dietary diversity score(DDS)was calculated according to the criteria in the Guidelines for Measuring Household and Individual Dietary Diversity released by the Food and Agriculture Organization of the United Nations.The body height(length)and body weight of each child were measured by standard equipment for anthropological measurement,and the height for age Z score(HAZ),weight for age Z score(WAZ),and weight for height Z score(WHZ) were calculated.Multivariate linear regression was performed to analyze the relationship between dietary diversity and growth indicators of children. Results A total of 1092 children were enrolled in this study,and the prevalence of stunting(HAZ<-2),underweight(WAZ<-2),and wasting(WHZ<-2)was 21.1%,4.9%,and 2.5%,respectively.The children had the mean DDS of 4.8±1.7,and 45.3% of children had poor dietary diversity(DDS≤4).The children of Han ethnic group(5.8±1.4)had higher DDS than those of Tibetan ethnic group(4.9±1.6)and Yi ethnic group(3.9±1.6)(P<0.001).The results of multivariate linear regression indicated that DDS was positively correlated with HAZ(β=0.206,95%CI=0.158-0.254,P<0.001)after adjustment of sex,age,birth weight,preterm birth,and parental body height.After further adjustment of family fixed assets,ethnic group,caregiver's type,and caregiver's education background,the correlation between DDS and HAZ remained significant(β=0.077,95%CI=0.026-0.128, P=0.003). Conclusions The children in the multi-ethnic rural areas of Sichuan province showed troublesome growth and development status and low dietary diversity,which were conspicuously different between ethnic groups,especially in the rural areas of Yi ethnic group.The dietary diversity was positively associated with HAZ.It is recommended to carry out nutrition and health education according to the local dietary characteristics and thus improve the growth and development of children in multi-ethnic rural areas in Sichuan.
Subject(s)
Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Pregnancy , China/epidemiology , Ethnicity , Growth and Development , Nutritional Status , Premature Birth , Rural PopulationABSTRACT
Objective To understand the status of physique and variational tendency of population in Chengdu,and comparing to the national level,for the purpose of providing evidence in improving the body mass among citizens in Chengdu.Methods Different groups were selected by cluster random sampling method,with a total of 5603 samples selected.Body shape,physiological and physical skills were measured according to the 2010 Workbook of Public Physique Monitoring Program and compared to the results from 2010.T test was used.Results For body shape,height and weight of the people in Chengdu were lower than the national average levels.Among them,males aged from 45 to 64 years old were 4.0 cm lower,females above 40 years old were 2.0 cm lower in height,when comparing to the national average levels with differences on weight as 3.5-6.4 kg for men and 1.7-3.2 kg for women.The chest,waist and hip circumferences of males were less than the national average levels,but showing at matching levels in women.Upper arm and abdominal skinfold in men were less than the national average,but the scapular skinfold was larger.Scapular skinfold was larger than the national levels,more than 7.1 mm in the 30 to 59 year-olds.Skin folds of the upperarm,shoulder and scapular in females were larger than the national levels.Citizens in Chengdu and the nation showed matching physiological levels.Physical skill of the adults was weaker than the national average level but the quality regarding power of gripping and time of reaction were superior in the elderly.Conclusion Levels of physique mass in Chengdu citizens were,in general,lower than the national average level.Elderly appeared having better physical quality,but not in the mid-aged adults.Our data suggested that a great effort should be made to improve the health of the mid-aged adults.
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical safety and effects of auto-dendritic cells pulsed with HLA-A201-binding peptides prostate-specific antigen (PSA) , prostate-specific membrane antigen (PSMA) and prostatic acid phosphatase (PAP) in the treatment of hormone-refractory metastatic prostate cancer (HRPC).</p><p><b>METHODS</b>Sixteen HRPC patients with positive HLA-A201 were enrolled and their monocytes isolated and induced into dendritic cells with the combination of rhGM-CSF and rhIL4. The patients were inoculated subcutaneously near the inguinal region with auto-DCs pulsed with peptides PSA (KLQCVDLHV) , PSMA (ALDVYNGL L) and PAP (LLHETDSAV) every 2 weeks for 4 times, and the immunological and clinical responses were examined within 1 -2 weeks after the final vaccination.</p><p><b>RESULTS</b>Vaccination of dendritic cells was well tolerated and no toxicity was observed. The cytokine levels in the serum such as IL-2, IL-12 and IFN-gamma were significantly increased after the vaccination (P < 0.01). The delayed type hyper- sensitivity (DTH) test was positive in 4 of the patients (4/11), the percentage of antigen-special IFN-gamma+ CD8+ T increased in 5 (5/11), the level of the tumor marker PSA decreased in 6 (6/16) , hydrops abdominis reduced in 1 (1/16), and the size of the cervical lymph node lessened in 1 (1/16). Three patients showed partial remission (PR), 7 stability of the disease (SD), and the other 6 progression of the disease (PD).</p><p><b>CONCLUSION</b>Auto-DC vaccines loaded with PSA, PSMA and PAP peptides, capable of eliciting specific immune responses in HRPC patients, is a safe and effective option for the treatment of advanced HRPC.</p>