ABSTRACT
Objective :To explore influencing factors of severity and aggravation of coronary heart disease (CHD ). Methods : A total of 132 CHD patients ,who were treated in our department from Mar 2015 to Mar 2017 ,were en-rolled .According to Gensini score ,patients were divided into mild disease group (n＝64) ,moderateand severe dis-ease group (n＝68).Relevant clinical data were collected ,and single-factor and multi －factor regression were used to analyze risk factors of coronary artery disease aggravation .Results :Clinical data indicated that diabetes mellitus (DM) ,smoking ,age ,body mass index (BMI) and blood lipids were influencing factors for coronary artery disease severity ( P＜0-05 or ＜0-01).Single factor regression analysis indicated that age ,smoking history ,DM history and dyslipidemia were influencing factors for coronary artery disease aggravation , P＜0-05 or ＜0-01 .Logistic multi－factor regression analysis indicated that dyslipidemia and smoking history were independent risk factors of aggrava-tion of coronary artery disease .(OR＝3-249 ,7-135 , P＝0-008 ,0-001).Conclusion : Severity of coronary artery disease is closely related with DM ,smoking history and dyslipidemia in CHD patients .And dyslipidemia and smok-ing history are independent risk factors for coronary artery disease aggravation .
ABSTRACT
This study aimed to observe the effects of spironolactone towards the rabbit atrial remodeling with rapid atrial pacing [RAP]. 30 rabbits were randomly divided into control group, RAP group and spironolactone group, with 10 rabbits in each group. RAP was performed at the speed of 800 beats/min for 8 h, atrial effective refractory period [AERP] was determined before and at the 1[st], 2[nd], 4[th], 6[th] and 8[th] of the pacing, the expressions of atrial muscular calcium channel alpha 1C subunit and beta 1 subunit mRNA were performed the RT-PCR detection, and ultrastructural changes of atrial myocytes were observed. AERP of RAP group shortened, with poor frequency adaptability; the expressions of calcium channel alpha 1C subunit and beta 1 subunit mRNA decreased 22% and 26%, respectively, when compared with the control group; ultrastructure of atrial myocytes changed significantly. AERP of spironotlactone group shortened less that RAP group, and the frequency adaptability was maintained, the decreased expressions of calcium channel alpha 1C subunit and beta 1 subunit mRNA significantly reduced. RAP could cause atrial remodeling, while spironolactone could inhibit RAPinduced atrial remodeling