ABSTRACT
Objective: To explore the anti-aging mechanism of polysaccharide from rhizomorph of Armillaria mellea (AMP) in Caenorhabditis elegans. Methods: With C. elegans as living model, the life span and the average number of offsprings were determined under normal culture conditions; The survival rate under oxidative stress and the expression of heat shock protein-16.2 (HSP-16.2) and superoxide dismutase-3 (SOD-3) were determined. Results: Under the normal culture conditions, the life span of C. elegans was significantly extended by AMP-1 and AMP-2 without the damage of the reproductive capacity; The expression of HSP-16.2 and SOD-3 was increased in C. elegans under the oxidative stress. Conclusion: The possible mechanism of AMP for anti-aging of C. elegans may be caused by increasing of the capacity of stress resistance.