ABSTRACT
Objective To study the expression of tumor type M2 pyruvate kinase(tumor M2-PK) in nonsmall cell lung cancer (NSCLC) and their correlation with treatment response and prognosis.Methods The concentration of tumor M2-PK in plasma was detected by ELISA in 106 healthy controls and 83 NSCLC patients.The patients were followed for 24 months.Results The patients after surgical operation showed marked reduction in plasma tumor M2-PK level(13.5 U/ml vs 25.4 U/ml,P<O.05).In the 15 patients with tumor remission the tumor M2-PK level(11.5 U/ml) was significantly lower than that(22.6 U/ml) before treatment(P<0.05).In the 20 patients with progressive disease the tumor M2-PK level(60.8 U/ml) was significantly higher than that(23.7 U/ml) of pretreatment(P<0.05).The tumor M2-PK concentration did not differ signigicantly before and after treatment in 17 patients with stable disease.The positive rates of tumor M2-PK decreased significantly after operation,but there was no significant change after chemotherapy.In the follow-up,the rate of relapse and metastasis was higher in patients Conclusions Plasma tumor M2-PK might be a useful marker in the detection of tumor mierometastases in NSCLC,and in evaluating treatment response and prognosis.
ABSTRACT
Objective To observe the changes of soluble interleukin-2 receptor(slL-2R) and high sensitivity C-reactive (hs-CRP) protein in renal allograft recipients and its relationship with rejective response of renal allograft. Methods The concentration of sIL-2R and hs-CRP were detected in 91 patients with renal allograft recipients and 100 health controls. CRP was measured by particle enhanced immuo-turbidimetric method, sIL-2R was detected by ELISA. Results The concentration of sIL-2R and hs-CRP in the recipients with acute rejec-tion was significantly higher than those without graft rejection and health controls. The concentration of hs-CRP in the recipients with chronic rejection was higher than those without graft rejection and health controls. There was no evidence of significant changes in the concentration of sIL-2R and hs-CRP between the health control group and the recipients without graft rejection. Conclusion slL-2R and hs-CRP might play an important role in graft rejection. The measurement of sIL-2R and hs-CRP is important for the diagnosis of graft rejection.