1.
Braz. j. med. biol. res
;
21(3): 577-83, Mar. 1988. ilus
Article
in English
| LILACS
| ID: lil-60268
ABSTRACT
Morphine and nalorphine were shown to have a peripheral effect on conscious guinea pigs, producing a decrease in the vocalization response to noxious electrical stimulation. Naloxone antagonized the effect of morphine and nalorphine. Locally administered clonidine had a peripheral effect on conscious guinea pigs, producing a decrease in the vocalization response to noxious electrical stimulation. The peripheral analgesia of clonidine was antagonized by yohimbine and naloxone. The analgesic effect clonidine was 250-300 times more potent than that of lidocaine. It is suggested that alfa2-adrenergic receptor agonists may active enkephalin-like substances released at the peripheral level
Subject(s)
Guinea Pigs , Animals , Analgesia , Clonidine/administration & dosage , Dose-Response Relationship, Drug , Electric Stimulation , Injections, Subcutaneous , Morphine/administration & dosage , Nalorphine/administration & dosage , Pain Measurement , Vocalization, Animal
2.
Braz. j. med. biol. res
;
19(3): 451-3, 1986. ilus
Article
in English
| LILACS
| ID: lil-37072
3.
Braz. j. med. biol. res
;
18(1): 79-86, 1985. ilus
Article
in English
| LILACS
| ID: lil-1163