Frenectomia labial em paciente com síndrome de Cornelia de Lange / Labial frenectomy in patient with Cornelia de Lange syndrome

Síndrome de Cornelia de Lange é uma anormalidade de desenvolvimento multisistêmica caracterizada por retardo cognitivo e de crescimento; dismorfia craniofacial, malformações dos membros superiores; disfunção geniturinária e oftalmológica, hirsutismo e anomalias cardíacas e gastroesofágicas. Cílios longos e sobrancelhas arqueadas com sinófiris, filtro longo com lábio superior fino. Ponte nasal deprimida com narinas antevertidas também ocorre com frequência. Problemas dentários são frequentes e incluem: palato ogival, micrognatia, atraso na erupção, erosão dental, doença gengival e periodontal. Com base nessas observações, o presente estudo tem como objetivo descrever a frenectomia labial em um paciente com síndrome de Cornelia de Lange, de 19 anos de idade, gênero masculino, bem como as recomendações para o manejo clínico e controle do biofilme dental

Cornelia de Lange syndrome is an abnormality multisystem developmental characterized by cognitive and growth retardation; craniofacial dysmorphia, malformations of the upper extremities, genitourinary and ophthalmologic dysfunction, hirsutism, cardiac and gastroesophageal abnomalies. Long eyelashes, arched eyebrows with synophrys, long philtrum with thin upperlip. Depressed nasal bridge with anteverted nares also frequently occur. Dental problems are common and include: high palate, micrognathia, delayed eruption, dental erosion, gingival and periodontal disease. Based on these observations, the present study aims to describe the labial frenectomy in a patient with Cornelia de Lange syndrome, 19 years old, male gender, as well as recommendations for the clinical management and control of dental biofilm

Effect of astaxanthin and fish oil on enzymatic antioxidant system and ?-amylase activity of salivary glands from rats

Salivary glands contribute to oral health. It is therefore of interest to study therapies that may favor their function and protection. AIM: To evaluate the effect of astaxanthin, fish oil and association of them on enzymatic antioxidant system and functional parameters of salivary glands. METHODS: Healthy rats (n=32) were divided into 4 groups: untreated-control, astaxanthin-treated (1 mg/kg body weight- BW), fish oil-treated (10 mg EPA/kg BW and 7 mg DHA/kg BW), and fish oil plus astaxanthin-treated. A prophylactic dose was administered in each group daily by gavage, for 45 days. Superoxide dismutase (SOD), catalase, glutathione peroxidase, reductase, and α-amylase activities were determined in salivary glands and compared by ANOVA and Tukey post-test (p<0.05). RESULTS: Parotid gland presented increased catalase and glutathione system and unaffected SOD activity after astaxanthin and astaxanthin plus fish oil treatment (p<0.05). Fish oil stimulated only glutathione peroxidase activity of parotid gland (p<0.05). Submandibular gland presented stimulated SOD and catalase, and reduced glutathione reductase activities after fish oil and fish oil plus astaxanthin treatment (p<0.05). SOD and glutathione reductase activities were reduced by astaxanthin treatment in submandibular gland (p<0.05). Parotid gland presented increased α-amylase activity in all groups supplemented and submandibular glands presented no changes (p<0.05). CONCLUSIONS: Astaxanthin, fish oil and combination of them stimulated the antioxidant system and functional parameter of salivary glands, which could be beneficial to oral health.