1.
Journal of Zhejiang University. Medical sciences
;
(6): 208-214, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-310365
ABSTRACT
Distant metastasis is the main cause of cancer death. Tetraspanins (transmembrane 4 superfamily, TM4SF) is capable of forming transmembrane complexes with integrin family participating in cell adhesion, migration and tumor metastasis. This review elucidates the structure of tetraspanins and its function in regulating metastasis as form of multimolecular transmembrane complexes with integrin.