ABSTRACT
Objective: To explore the feature and influencing factors of anhedonia in schizophrenia. Methods: A total of 71 schizophrenia patients and 50 healthy controls were recruited during December 2018 and December 2019. Positive and Negative Syndrome Scale (PANSS) was used for assessing psychotic symptoms. Temporal Experience of Pleasure Scale (TEPS) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were applied to the evaluation of anhedonia and cognitive function respectively for each subject. Results: The evaluation result of TEPS showed both anticipatory and consummatory pleasure scores were lowered in patients with schizophrenia than those in healthy people (P=0.000). Stepwise linear regression analysis showed that negative subscale score of PANSS (B=-0.895, P=0.002) and delayed memory score of RBANS (B=0.265, P=0.001) were associated with anhedonia in schizophrenia. Conclusion: Patients with schizophrenia exhibit anticipatory and consummatory anhedonia, both of which are influenced by negative symptoms and delayed memory in schizophrenia.
ABSTRACT
Depression is a common mental disorder and causes great disease burden. To date people's understanding of genetic mechanisms of depression is lagging far behind that of other psychiatric disorders such as schizophrenia and bipolar disorder. Recently, with the accumulation of clinical samples and the advances of methodology and technology, certain progress in genetics of depression has been made. This review summarizes the genetic research progress in candidate genes, common variants, rare variants and chromosome structure variations of depression.
ABSTRACT
Objective To provide some evidence for choosing the strategy for conducting micturating cystourethrography(MCU) examination in infants under 2 years old with urinary tract infection(UTI) by comparing the clinical examinations in patients under 2 years old with and without vesicoureteral reflux.Methods One hundred and twelve inpatients from Yuying Children's Hospital,Wenzhou Medical University,under 2 years old with UTI from Jan.2009 to Dec.2011 were collected,The incidence of vesicoureteral reflux(VUR) among 3 groups(＜ 6 months old,6 months to 1 year old and 1 to 2 years old) was analyzed and the differences in body temperature,white blood cell,C-reacting protein (CRP),urinary β2-microglobulin (β2-MG),urine N-acety1 glucosaminidase (NAG),ultrasound examination (USG)anomaly and dimercaptosuccinic acid (DMSA) anomaly between VUR positive and negative patients were compared.Results The detection rate of VUR and the grade of regurgitation were not statistically different in each age group of infants under 2 years old with UTI.There were 10 cases with urine β2-MG increasing in VUR positive group,significantly higher than those in the VUR negative group(6 cases) (P ＜0.01),but there was no difference in others.Conclusions The urine β2-MG increasing is the intense indication for performing MCU in infant under 2 years old with UTI,and the possibility of VUR in these patients even without fever should also be vigilant.