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Gac. méd. Méx ; 155(3): 223-228, may.-jun. 2019. tab, graf
Article in English, Spanish | LILACS | ID: biblio-1286495

ABSTRACT

Abstract Introduction: The management of kidney transplant recipients requires glomerular filtration rate (GFR) monitoring, which is an indicator of graft primary function and patient survival. Objective: To evaluate the performance of different creatinine or cystatin-based formulas in the estimation of glomerular filtration rate in Mexican patients receiving kidney transplantation. Method: 30 transplant recipients were included, in whom the glomerular filtration rate was measured by means of iothalamate, and was also calculated using seven equations based on cystatin or creatinine. Results: The formula with the best performance was the one proposed by the chronic kidney disease epidemiology collaboration (CKD-EPI), with a bias of −2.4 mL/min/1.73 m2: and an accuracy of 9.6; 96.7 % of patients were within 30 % of the measured GFR. The second best formula was the modification of diet in renal disease (MDRD) equation. Cystatin-based equations showed a poor performance. Conclusions: Our study suggests that, in Mexican patients receiving kidney transplantations, the best equations to estimate GFR are the CKD-EPI and MDRD equations.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Kidney Transplantation/methods , Creatinine/analysis , Renal Insufficiency, Chronic/surgery , Cystatin C/analysis , Glomerular Filtration Rate/physiology , Reproducibility of Results , Kidney Function Tests , Mexico
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