Síndrome de Hedinger / Hedinger syndrome

Resumen La afectación cardíaca por tumor carcinoide (síndrome de Hedinger) sigue siendo una causa importante de morbilidad y mortalidad entre los pacientes con síndrome carcinoide y tumores neuroendocrinos metastásicos. El estudio de imagen inicial ante la sospecha clínica es el ecocardiograma transtorácico, el cual es importante para la detección temprana de la afectación cardíaca. La cirugía cardíaca, en casos apropiados, es la única terapia definitiva para el tumor carcinoide con afectación cardíaca y mejora los síntomas del paciente y la supervivencia. El tratamiento es complejo y multidisciplinario; el estado cardíaco, el síndrome hormonal y la carga tumoral son fundamentales para guiar el momento óptimo de la cirugía. Se presenta el caso de una paciente joven, con síndrome de Hedinger con afectación valvular tricúspide y pulmonar, quien recibió tratamiento quirúrgico y tuvo evolución exitosa.

Abstract Cardiac carcinoid tumor involvement (Hedinger's syndrome) remains a major cause of morbidity and mortality among patients with carcinoid syndrome and metastatic neuroendocrine tumors. The initial imaging study in case of clinical suspicion is the transthoracic echocardiogram, which is important for the early detection of cardiac involvement. Cardiac surgery, in appropriate cases, is the only definitive therapy for carcinoid tumor with cardiac involvement and improves patient symptoms and survival. Treatment is complex and multidisciplinary; cardiac status, hormonal syndrome, and tumor burden are essential to guide the optimal timing of surgery. The case of a young female patient with Hedinger's syndrome with tricuspid and pulmonary valve involvement, who received surgical treatment and had a successful evolution.

The association between perceived level of COVID-19-related eHealth literacy and adherence to preventive practices against COVID-19 infection among adult patients in healthway family clinics in Marikina and Rizal: An analytical cross-sectional study

Background@#The internet contains both accurate and false coronavirus-related information. Is the public equipped with electronic health literacy in navigating online material to make informed health decisions?@*Objective@#This study measured Filipino adults’ perceived level of COVID-19-related eHealth literacy, and how this affects their adherence to preventive practices against COVID-19 infection.@*Methods@#In this analytical cross-sectional study, data were collected from 345 adult respondents who were patients, and their companions, consulting in Healthway Family Clinics in Marikina and Rizal. They answered self-administered electronic questionnaires in English or Filipino. The data collection tool was adapted from the Coronavirus-Related eHealth Literacy Scale (CoV-eHEALS) with permission from the authors. Pearson correlation determined the relationship between mean CoV-eHEALS and mean Protective Behavior Adherence (PBA) score. ANOVA determined the relationship of CoV-eHEALS and PBA with sociodemographic variables. @*Results@#Higher Covid-related eHealth literacy is associated with better adherence to protective behaviors against COVID-19. The overall mean CoV-eHEALS is 23.67 while the overall mean PBA score is 3.81 (r=0.32). Younger age, female sex, and high educational attainment are associated with high CoV-eHEALS. Female sex and high educational attainment are associated with high PBA score@*Conclusion@#eHealth literacy is essential for COVID-19 awareness since it influences the public‘s engagement in preventive behavior. Sociodemographic variables should be considered in health education, targeting individuals of younger age, male sex, and lower education. Evaluation of the reliability of online sources Filipinos use to gather health-related information is a possible focus for future research.

Melanoma Lentiginoso Acral Revisión Narrativa de uno de los Melanomas más Frecuentes en América Latina / Acral lentiginous melanoma: Review of one of the most frequent melanomas in Latin America

Resumen El melanoma es el cáncer de piel con mayor tasa de mortalidad a nivel mundial. Se han descrito 4 subtipos principales de melanoma cutáneo: el melanoma de extensión superficial, el melanoma nodular, el léntigo maligno y el melanoma lentiginoso acral. Existen diferencias raciales y geográficas en la distribución y frecuencia de estos subtipos. En caucásicos, el riesgo es mayor para melanomas de piel expuesta a radiación UV, ya sea de forma crónica o intermitente. En contraste, en asiáticos, afroamericanos e hispanos, la tendencia es mayor en sitios anatómicos no expuestos (palmas y plantas), encabezando el melanoma lentiginoso acral en una proporción mayor. Usualmente, este melanoma se diagnostica de manera tardía y en estadios avanzados, por cual se asocia con un peor pronóstico. La presente revisión pretende brindar una visión general sobre el conocimiento del melanoma lentiginoso acral, describiendo aspectos como la epidemiología, los factores de riesgo asociados, las características genéticas y los factores pronósticos.

Abstract Melanoma is the cutaneous cancer with the highest mortality worldwide. Four main subtypes of cutaneous melanoma have been described: superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma, and acral lentiginous melanoma. There are racial and geographical differences in the distribution and frequency of these subtypes. In Caucasians, the risk is higher to develop melanoma on skin exposed to UV radiation, either chronically or intermittently. In contrast, in Asians, African Americans, and Hispanics, there is a greater tendency towards unexposed anatomical sites (palms and soles), which is called acral lentiginous melanoma. This melanoma is usually diagnosed in advanced stages, and therefore has a worse prognosis. This review aims to provide an update on what is known about acral lentiginous melanoma, mainly describing its epidemiology, risk factors associated with genetic characteristics, and prognosis.

Parámetros zootécnicos de Cavia porcellus en sistemas productivos de Nariño y Putumayo (Colombia) / Zootechnical parameters of Cavia porcellus in production systems in Nariño and Putumayo (Colombia) / Parâmetros zootécnicos de Cavia porcellus em sistemas de produção em Nariño e Putumayo (Colômbia)

Resumen El cuy (Cavia porcellus) es una especie que tiene importancia social y cul- tural en la región sur occidental de Colombia. El objetivo de este trabajo fue identificar el comportamiento de variables productivas y reproductivas del cuy en Nariño y Putumayo. Se aplicó una encuesta en 404 sistemas productivos de los municipios de Pasto-Nariño y Colón, San Francisco, Santiago y Sibundoy-Pu- tumayo. Los datos fueron procesados en el programa IBM-SPSS-Statistics® V. 20.0- 2011. La distribución de la población de cuyes correspondió a cruces de varias líneas con ascendencia de: Criolla-Perú-Andina 61,4%, Criolla-14,8%, sin identificar 13,4%, Perú 9,65% y Andina 0,74%. La edad a la primera monta (meses) fue menor para Perú (5,1) y Andina (4,5) que en animales criollos (5,3). El número partos/hembra/año en las líneas Perú y Andina fue de 3,7 en hembras criollas fue de 3,4. El 97,3% de los productores han establecido grupos de monta donde la relación macho: hembras, por líneas fue de 1:6, 1:8 y 1:4 para Criolla, Perú y Andina respectivamente. Los pesos promedio (g) al nacimiento, destete y beneficio fueron: 222, 413 y 1330 (Criolla), 197, 390 y 1259 (Perú) y 125, 450 y 1300 (Andina) respectivamente. La edad al destete (días) fue de 24,5 (Criollos), 19,3 (Perú) y 18,3 días (Andina). Se evidenció predominan- cia en el uso de líneas criollas y/o cruces. Las líneas Perú y Andina reportaron mayor eficiencia reproductiva, la línea criolla presentó una mayor eficiencia productiva. Por el potencial del sistema es acertado realizar una caracterización más amplia.

Abstract The guinea pig (Cavia porcellus) is a species of social and cultural impor- tance in the southwestern region of Colombia. However, information on zootechnical variables is under development. The objective of this work was to identify the behavior of lines, productive and reproductive vari- ables of guinea pigs in Nariño and Putumayo. A survey was applied in 404 productive systems of the municipalities of Pasto-Nariño and Colón, San Francisco, Santiago and Sibundoy-Putumayo. The data were processed in the program IBM-SPSS-Statistics® V. 20.0-2011. The distribution of lines corresponded to crosses: Criolla-Peru-Andina 61.4%, Criolla-14.8%, un- identified line 13.4%, Peru 9.65% and Andina 0.74%. The age at first mating (months) was lower for the Peruvian (5.1) and Andean (4.5) lines than in Creole animals (5.3). The number of births/ females/years in the Peru- vian and Andean lines was 3.7 in Creole females was 3.4. The 97.3% of the producers have established groups of mount where the relation male: females, by lines was of 1:6, 1:8 and 1:4 for Criolla, Peru and Andina respec- tively. The average weights (g) at birth, weaning and benefit were: 222, 413 and 1330 (Criolla), 197, 390 and 1259 (Peru) and 125, 450 and 1300 (Andina) respectively. The age at weaning (days) was 24.5 (Criollos), 19.3 (Peru) and 18.3 days (Andina). It was evidenced predominance in the use of Creole lines and/or crosses. The Peruvian and Andean lines reported greater re- productive efficiency, the Creole race presented a greater productive ef- ficiency. Due to the potential of the system, it is pertinent to carry out a broader characterization.

Resumo A cobaia (Cavia porcellus) é uma espécie de importância social e cultural na região sudoeste da Colômbia. No entanto, a informação sobre as variáveis zootécnicas está em desenvolvimento. O objetivo deste trabalho foi identificar o comportamento das variáveis do linhas, produtivas e reprodutivas das cobaias em Nariño e Putu- mayo. Foi aplicado um levantamento em 404 sistemas produtivos dos municípios de Pasto-Nariño e Colón, São Francisco, Santiago e Sibundoy-Putumayo. Os dados foram processados no programa IBM-SPSS-Statistics® V. 20.0-2011. A distribuição da população correspondeu a cruzamentos de várias linhagens com ascendência de: Crioulo-Peru-Andina 61,4%, Crioulo-14,8%, biótipo não identificado 13,4%, Peru 9,65% e Andina 0,74%. A idade no primeiro acasalamento (meses) foi menor para os biótipos Peru (5,1) e andinas (4,5) do que em crioulo (5,3). O número de nascimentos/ fêmea/ano nos biótipos peru e andino foi de 3,7 em fêmeas crioulas foi de 3,4. 97,3% dos produtores estabeleceram grupos de acasalamento onde a proporção macha/ fêmea em linhas foi de 1:6, 1:8 e 1:4 para o crioulo, peru e andino respectivamente. Os pesos médios (g) no nascimento, desmame e benefício foram: 222, 413 e 1330 (crioulo), 197, 390 e 1259 (peruano) e 125, 450 e 1300 (andino), respectivamente. A idade de desmame (dias) foi de 24,5 (Crioulo), 19,3 (Perú) e 18,3 dias (Andina). Foi comprovada predominância no uso de linhas e/ou cruzamentos crioulos. As linhas Peru e Andinas relataram maior eficiência reprodutiva, a linha crioula apresentou maior eficiência produtiva. Devido ao potencial do sistema, é aconselhável realizar uma caracterização mais ampla.

Necesidad de tratamiento de maloclusiones y su influencia en la calidad de vida de estudiantes de educación secundaria de la ciudad de Puno, 2018 / Necessity of treatment of malocclusions and its influence on the quality of life of students of secondary education of the city of Puno, 2018

Objetivo. Determinar la Necesidad de Tratamiento de Maloclusiones y su Influencia en la Calidad de Vida de Estudiantes de Educación Secundaria de la Ciudad de Puno, 2018. Materiales y métodos. Se realizó un estudio descriptivo, cualitativo, transversal; la muestra estuvo conformada por 354 adolescentes de 11 a 14 años. Se utilizó el instrumento de autopercepción del Componente Estético (CE) del INTO y el Componente de Salud Dental (CSD) del INTO por el Especialista, examinando la cavidad bucal de los Escolares, además de aplicar el instrumento CPQ11-14, que midió la calidad de vida, ambos instrumentos cuentan con validación Resultados. Se muestra una relación directa y proporcional entre las variables, el modelo se ajusta con un R2 de 97%, lo cual dice que estas variables están fuertemente asociadas. Se determinó la ecuación de estimación y predicción del impacto en la CVRSB, en base al valor del componente estético. Donde Y sería el impacto en la calidad de vida y X sería el valor del componente estético del instrumento INTO. (AU)

Objectives: To determine the Need for Treatment of Malocclusions and its Influence on the Quality of Life of Secondary Education Students of the City of Puno, 2018. Material and Methods: This study was descriptive, relational, transversal. 354 children were assessed, to whom the instrument of self-perception of the aesthetic component (CE) of the INTO and the Dental Health Component (CSD) of the INTO was applied by the Specialist, examining the oral cavity of the Schoolchildren, finally the instrument CPQ11-14 was applied, which measured the quality of life with validation, both instruments. Results: A direct and proportional relationship between the variables is shown, the model is adjusted with an R2 of 97%, which says that these variables are strongly associated. The equation of estimation and prediction of impact on CVRSB was determined, based on the value of the aesthetic component. Where and would be the impact on the quality of life and X would be the value of the aesthetic component of the INTO instrument. Conclusion: There is a very strong and positive correlation between the aesthetic component and the impact on the quality of life in schoolchildren of state schools of the city of Puno. (AU)

Potencial leiteiro de animais da raça Pantaneira na região do Alto Pantanal do Mato Grosso do Sul / Dairy potential of pantaneira breed upper region of pantanal of Mato Grosso Sul

The Pantaneira breed is in danger of extinction. Due to the lack of scientific information on the Pantanal milk potential, this work had the objective of determining the lactation period and a physical-chemical composition of the milk of cows in second order of parturition. The animals were managed in a pasture system rotated in mombaça grass (Panicum maximum) and individually supplemented with concentrate. The milking was performed mechanically twice a day and the milk weighed daily. The physical-chemical characteristics of the milk were evaluated by the ultrasound method and the lactation curves were estimated using the univariate parameter. The average milk yield was 5.34kg/milk/ day and the fat, protein, lactose and total non-fat solids contents were 5.3, 3.7, 6.0 and 10.7%, respectively. Lactation of the cows in second order of calving ended naturally at 180 days and the peak of milk production was reached between 51 and 60 days. Furthermore, there was no difference in milk composition in the different lactation periods.(AU)

Physiological response of invasive mussel Limnoperna fortunei (Dunker, 1857) (Bivalvia: Mytilidae) submitted to transport and experimental conditions / Resposta fisiológica do mexilhão invasor Limnoperna fortunei (Dunker, 1857) (Bilvalvia: Mytilidae) submetido ao transporte e condições experimentais

Abstract Successful animal rearing under laboratory conditions for commercial processes or laboratory experiments is a complex chain that includes several stressors (e.g., sampling and transport) and incurs, as a consequence, the reduction of natural animal conditions, economic losses and inconsistent and unreliable biological results. Since the invasion of the bivalve Limnoperna fortunei (Dunker, 1857) in South America, several studies have been performed to help control and manage this fouling pest in industrial plants that use raw water. Relatively little attention has been given to the laboratory rearing procedure of L. fortunei, its condition when exposed to a stressor or its acclimation into laboratory conditions. Considering this issue, the aims of this study are to (i) investigate L. fortunei physiological responses when submitted to the depuration process and subsequent air transport (without water/dry condition) at two temperatures, based on glycogen concentrations, and (ii) monitor the glycogen concentrations in different groups when maintained for 28 days under laboratory conditions. Based on the obtained results, depuration did not affect either of the groups when they were submitted to approximately eight hours of transport. The variation in glycogen concentration among the specimens that were obtained from the field under depurated and non-depurated conditions was significant only in the first week of laboratory growth for the non-depurated group and in the second week for the depurated group. In addition, the tested temperature did not affect either of the groups that were submitted to transport. The glycogen concentrations were similar to those of the specimens that were obtained from the field in third week, which suggests that the specimens acclimated to laboratory conditions during this period of time. Thus, the results indicate that the air transport and acclimation time can be successfully incorporated into experimental studies of L. fortunei. Finally, the tolerance of L. fortunei specimens to the stressor tested herein can help us understand the invasive capacity of this mussel during the establishment process.

Resumo A criação bem sucedida de animais em condições de laboratório para processos comerciais ou experimentais é uma cadeia complexa que inclui vários fatores de estresse (ex. coleta e transporte) que tem como consequência a redução das condições naturais do animal, prejuízos econômicos e resultados biológicos inconsistentes. Desde a invasão do bivalve Limnoperna fortunei (Dunker, 1857) na América do Sul, vários estudos têm sido realizados para ajudar no controle e gestão dessa praga em plantas industriais que utilizam água. Relativamente pouca atenção tem sido dada ao processo de criação de L. fortunei em laboratório, sua condição quando exposta ao estresse e sua aclimatação a condições de laboratório. Considerando estes aspectos, os objetivos deste estudo foram: (i) investigar as respostas fisiológicas de L. fortunei submetidos ao processo de depuração e subsequente transporte (sem água/condição seca) em duas temperaturas, analisando as diferentes concentrações de glicogênio e (ii) monitorar as concentrações de glicogênio nos diferentes grupos, quando mantidos por 28 dias em condições de laboratório. Com base nos resultados obtidos, a depuração não afetou nenhum grupo quando eles foram submetidos a oito horas de transporte. A variação da concentração de glicogênio entre os espécimes do campo quando depurados e não depurados, foi significativa apenas em relação à primeira semana em laboratório para o grupo não depurado e à segunda semana para o grupo depurado. Além disto, a temperatura testada não afetou os grupos submetidos ao transporte. As concentrações de glicogénio foram semelhantes as dos espécimes do campo a partir da terceira semana, o que sugere que os espécimes estão aclimatados às condições de laboratoriais neste período de tempo. Assim, os resultados indicam que o transporte ao ar e o tempo de aclimatação podem ser incorporados com sucesso aos estudos experimentais com L. fortunei. Finalmente, o conhecimento sobre a tolerância de L. fortunei ao estresse pode ajudar a entender a capacidade invasiva deste durante o processo de estabelecimento.

Breast cancer awareness among female non-medical college students in Quezon City / The Health Sciences Journal

Introduction@#Breast cancer remains to be a public health problem in the Philippines. This study determined the level of breast cancer awareness among female non-medical students from selected private colleges in Quezon City. @*Methods@#This was a descriptive cross-sectional survey, and data collection was done on a single occasion. The study population was chosen via convenience sampling. The survey asked about the respondents' ideas on awareness, beliefs, perceived personal risk, perceived seriousness, and knowledge of etiology, diagnosis and management of breast cancer.@*Results@#Majority of the respondents associated lifestyle factors (smoking) with the development of breast cancer. Four-fifths regarded Western medicine as a mainstay of treatment, however, a significant proportion believed that breast cancer could be adequately managed and controlled with complementary and alternative treatments. Around 25% of respondents considered themselves at risk for breast cancer and 40% did not know. Close to 65% said that family history was a risk factor. Almost 50% never heard of self-breast examination; of those who knew about it, only 15% practiced it monthly. The respondents had varied answers when asked about the common symptoms and signs of breast cancer. At least two-thirds of respondents said that the treatment for breast cancer includes surgery and radiation therapy. Majority (79.8%) opined that having an education program would increase the level of awareness of the general public.@*Conclusion @#The students surveyed were generally aware about breast cancer, including aspects of epidemiology, diagnosis and management. The study also a revealed a number of misconceptions regarding breast cancer.

Diseño de un instrumento para medir estigma hacia la tuberculosis

Introducción: La tuberculosis continúa siendo un problema en salud pública con alta carga de la enfermedad. El efecto del estigma en el control de la TBC es desconocido porque se han realizado pocos estudios formales sobre el tema. Objetivo: Desarrollar un instrumento para medir el estigma hacia la TBC. Materiales y métodos: Estudio de evaluación de tecnología diagnóstica, con diseño del instrumento bajo las recomendaciones de Wolfe y Smith, basados en el modelo de análisis Rasch. Resultados: Se diseñó un instrumento con 35 ítems, que presentaron una adecuada comprensión por parte de las personas evaluadas. Conclusiones: El instrumento diseñado contribuirá en la medición de este constructo y en la comprensión de sus efectos en el control de la TBC.

Introduction: Tuberculosis remains a public health problem with high burden of disease. The effect of stigma in TB control is unknown because there have been too few formal studies on the subject. Objective: To design an instrument to measure the tuberculosis stigma. Methodology: Study of diagnostic technologies evaluation, aiming at the elaboration of an instrument based on the Rasch- Analysis in accordance with the recommendations of Wolfe and Smith. Results: An instrument has been designed featuring 35 items that had been adequately understood by the persons assessed. Conclusions: The tool designed will contribute to measuring stigma and to understanding its impact on TB control.

Helmintos oxiuridae parasitos de Iguana iguana (Squamata, Lacertilia, Iguanidae) procedentes do Brasil / Oxiuridae helminths parasites of Iguana iguana (Squamata, Lacertilia, Iguanidae) in Brazil

The results of a study on nematode fauna occurring in wild iguanas (Iguana iguana) from Brazilian Northeast (Alagoas and Maranhão) and Central-west (Goiás and Mato Grosso) areas were presented. Six adult iguanas, three males and three females, were necropsied and the digestive system removed to examination. All the iguana specimens were heavily parasitized. The helminths diagnosed were: Ozolaimus cirratus in the cecum and colon of five iguanas; Ozolaimus megatyphlon in cecum, colon and rectum of three iguanas; and Alaeuris vogelsangi in the small intestine, cecum, colon and rectum of five animals. Two larvae of Ozolaimus sp. were recovered from the pyloric region of the stomach of one iguana. The three diagnosed species of nematodes were reported for the first time in the Brazilian Central-West region.

Eritrograma e variantes de hemoglobina em caprinos da raça Canindé / Erythrogram and hemoglobin types in Canindé goats

The erythrogram and hemoglobin types in Canindé goats were determined. Twenty blood samples were collected from the animals and used for determination of packed cell volume (PCV), erythrocytes counts, hemoglobin concentration, calculation of mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC), and electrophoretic separation of hemoglobin types. The values for erythrogram were: PCV 34.6±4.62 percent, hemoglobin 10.1±1.05mg/dl, erythrocytes 15.3±4.54x106/mm3, MCV 24.0±5.83fl, and MCHC 29.3±2.44g/dl. Electrophoretic separation of hemoglobin types revealed only one type characterized as hemoglobin A (HbAA).

Caracterización epidemiológica de una población de pacientes del programa ®manejo integral de la enfermedad pulmonar obstructiva crónica¼ de la EPS Sanitas en Bogotá / Patient characteristics and diagnostic evaluation in a management programme of Chronic Obstructive Pulmonary Disease (COPD) in Bogota (2640m), Colombia

Objetivo: describir las características epidemiológicas de los pacientes al ingreso a un programa de manejo integral de la EPOC en Bogotá. Material y método: estudio de corte transversal. Evaluamos 756 pacientes con diagnóstico presuntivo de EPOC. Se confirmaron 408 por espirometría (54 por ciento), de los cuales se excluyeron 57. Se describen las características demográficas, clínicas, paraclínicas de 351 pacientes y su asociación con el grado de severidad de la obstrucción. Análisis estadístico: Se presentan las frecuencias y medidas de tendencia central y dispersión. Se utilizó el coeficiente paramétrico de Pearson o el coeficiente no-paramétrico de Spearman según normalidad, a un nivel de significancia del 1 por ciento (p<0.01). Resultados: La EPOC, definida por una relación VEF1/CVF < 70 por ciento, post-broncodilatador, se confirmó en el 54 por ciento de los pacientes. La edad promedio fue 72,8±9 años, 61 por ciento hombres, fumadores activos 9,1 por ciento, expuestos a humo de leña 33,3 por ciento. El 68,6 por ciento no utiliza correctamente los inhaladores. El VEF1 promedio fue 1.285±517 litros. El 68,1 por ciento y 46,4 por ciento no se habían vacunado contra neumococo e influenza respectivamente. Se encontró correlación directa y significativa entre VEF1 (por ciento) con saturación, PaO2 e índice de masa corporal; e inversa con PCO2, hematocrito e índice de disnea; no se encontró correlación con la escala de calidad de vida (S. George) y test de marcha en 6 minutos. Conclusiones: El 54 por ciento de los pacientes remitidos están adecuadamente diagnosticados. Hay baja cobertura en vacunación contra neumococo e influenza, la mayoría utilizan en forma incorrecta los inhaladores. Resaltamos la importancia de utilizar la espirometría como herramienta básica en el diagnóstico de EPOC, al igual que programas educativos que impacten en el manejo de la EPOC. (Nota el enlace a Internet opera para todo el fasciculo 1/2008).

Aplicacion del modelo diagnostico del grupo internacional para la hepatitis autoinmune (GIHA) en una poblacion de pacientes de Medellin, Colombia / Applicability of scoring system proposed by the International Autoinmune Hepatitis group (IAHG) at Medellin's hospital

Objetivo; evaluar la aplicabilidad del modelo diagnóstico propuesto por el Grupo Internacional de Hepatitis Autoinmune (G1HA). Metodología: estudio retrospectivo, observacional, no analítico de 28 pacientes con diagnóstico de Hepatitis Autoinmune (HA1) de la ciudad de Medellín- Colombia. Resultados; se analizaron 28 pacientes con diagnóstico de HAI. Según el modelo de criterios diagnósticos de 1992 aplicado a los pacientes antes del inicio del tratamiento, 25 por ciento tuvieron diagnostico definitivo y 53 por ciento diagnóstico probable. Al aplicar los nuevos criterios, 14 por ciento tenían diagnostico definitivo y 64 por ciento probable. En ambos modelos 22 por ciento de los pacientes no alcanzaron el puntaje para clasificarlos como HA1. La concordancia entre el diagnóstico clínico y los criterios del GIHA fue de 78. 5 por ciento con ambos puntajes. Conclusiones: ambos modelos son útiles para el diagnóstico de hepatitis autoinmune. El modelo de 1998 es más especifico en nuestro estudio

Dermatofitos en perros de Cali, Colombia / Dermatophytes in dogs from Cali, Colombia

En Cali se realizó un estudio de perros con el fin de determinar la frecuencia de dermatofitos. La toma de muestra se hizo en hocico, cabeza, dorso, vientre y zonas laterales por la técnica del tapete y para cada sitio y perro muestreado se utilizó una alfombra diferente. Las muestras se sembraron en agar selectivo para hongos patógenos. Se examinaron 251 perros, 86 callejeros y 165 caseros, entre los cuales se encontraron 34 (13,5 por ciento) positivos para dermatofitos; de éstos, 23 correspondieron a perros caseros y 11 a callejeros. No se establecieron diferencias significativas entre estas dos categorías. Tampoco se encontró asociación con la edad, el sexo, la raza o la longitud del pelo, pero sí hubo relación entre la presencia de lesiones en la piel y el aislamiento de hongos (P<,0,05). El dermatofito más aislado fue el Microsporum gypseum (55,9 por ciento), seguido por Microsporum canis y Trichophyton mentagrophytes var mentagrophytes, cada uno con el 14,7 por ciento y Trichophyton rubrum con 2,9 por ciento de los aislamientos. Estos dos últimos hongos sólo se hallaron en los perros caseros

Dengue infection in Paracambi, State of Rio de Janeiro, 1990-1995

Um inquérito soroepidemiológico foi realizado em uma amostra de escolares, em 1994, no município de Paracambi, Estado do Rio de Janeiro. Positividade do teste de Inibição da Hemaglutinação foi detectada em 39,2% (145/370) dos escolares pesquisados. A freqüência de positividade foi de 53,8% (78/145) para o sexo feminino e de 46,2% (67/145) para o sexo masculino. A distribuição por faixa etária mostrou uma positividade crescente com o aumento da idade. Cepas do vírus dengue tipo 1 e vírus dengue tipo 2 foram isoladas anteriormente (1990), mostrando a co-circulação de ambos os sorotipos na área. Os índices de infestação predial pelo Aedes aegypti e pelo Aedes albopictus foram determinados.

A seroepidemiological survey was carried out during 1994 in the municipality of Paracambi, state of Rio de Janeiro. Haemagglutination inhibition test positivity was detected in 145 out of 370 (39.2%) schoolchildren. The frequency of positive test by sex was 53.8% (78/145) female and 46.2% (67/145) male. Distribution by age showed the increasing of antibody positivity in older children. Strains of dengue virus type 1 and dengue virus type 2 were isolated before (1990) showing the co-circulation of both serotypes in that area. The house index infestation of Aedes albopictus and Aedes aegypti has been determined.

Influencia del coralán sobre la respuesta in vitro de células inmunocompetentes / Coralan influence on the in vitro response of inmunocompetent cells

El coralán, aislado de la Pseudopterogorgia americana, un coral blando, es una glicoproteìna sulfatada que contiene 1% de sulfato, se ha informado que tienen influencia en el rechazo del trasplante del tumor ascìtico de Ehrlich. Diferentes concentraciones de esta sustancia se probaron en células mononucleares de sangre periférica (CMN) frente a la PHA, se observó un incremento significativo de la respuesta, lo que indica que una de las vías por las que este producto ajerce su actividad es por la vía de los linfocitos T. Tambièn se produce un ligero incremento de la actividad de las células NK frente a las células K 562 cuando las CMN son preincubadas con el producto 2 horas antes de realizarse el experimento, datos que en nuestras condiciones fueron comparables al procucido por el IFN, que se ha descrito que aumenta esta actividad.

Ensayo de estabilidad para nitrofurazona crema / Stability assay for nitrofurazone cream

Se analiza un estudio de la estabilidad del preparado. Las muestras se colocan a varias temperaturas posteriormente se analizaron por espectofotometría en la zona ultravioleta. Además se realizan ensayos cromatográficos utilizando como solvente una mezcla de benceno acetona 3-2. Se realiza un ensayo comparativo de las muestras colocadas a diferentes temperaturas. Se le da fecha de vencimiento de acuerdo con los resultados obtenidos