Effect of 12 weeks life-style activity modification on serum oxidized LDL-C in obese men

Exercise significantly prevents the progression of atherosclerosis and oxidized LDL-C [ox-LDL-C], facilitates monocyte-related atherogenesis. The effects of Lifestyle Activity Modification [LAM] training based on guidelines of the Centers for Disease Control [CDC] and the American College of Sports Medicine [ACSM] on serum oxidized LDL-C [ox-LDL-C] in obese people are not well known. We investigated the effect of LAM on serum ox-LDL-C in obese middle aged men. Sixteen healthy obese middle aged men [aged 42.06 +/- 6.01 years, mean +/- SD] were randomly assigned to the LAM [n=8] and the control [n=8] groups. Subjects in the LAM group walked 2 miles daily in 30 minutes 4 days weekly for 12 weeks on treadmills, according to the CDC and ACSM guidelines. Results showed that body weight, BMI, body fat mass, body fat percent, waist to hip ratio [WHR] and LDL-C decreased significantly after 12 weeks in the LAM group compared to the controls [P<0.05], and their maximum oxygen uptake was increased significantly compared to the controls after 12 weeks [P<0.05]. On the other hand, after 12 weeks of LAM training, no significant differences were observed in serum ox-LDL-C, total cholesterol [TC], triglycerides [TG] and HDL-C between the groups. Although twelve weeks of LAM improved body composition and cardio-respiratory fitness and decreased LDL-C levels in obese middle aged men, serum ox-LDL-C were not affected by this protocol in this group

[Effects of 12 weeks walking on plasma adiponectin concentration in postmenopausal women with breast Cancer]

Adiponectin is involved in breast cancer development, and data available suggest that exercise increases plasma adiponectin, but little is known about the effect of exercise on plasma adiponectin in postmenopausal women with breast cancer. The purpose of this study therefore was to examine the effects of 12 weeks of walking on plasma adiponectin in postmenopausal women with breast cancer. Nineteen postmenopausal women with breast cancer [aged 55 +/- 2.7 years; mean +/- SD] who had undergone surgery, chemotherapy and radiotherapy, with hormone therapy by letrozol, were divided into the training [n=11] and control [n=8] groups. Subjects in the experimental group walked 25 to 45 minutes with intensity of 45 to 65% of target heart rate, 4 days for 12 weeks. The results showed that maximum oxygen uptake increased and fasting insulin decreased significantly after 12 weeks in the training group, as compared to the control group [P<0.05]. However, after 12 weeks walking no significant differences were observed in the plasma adiponectin, fasting glucose and insulin resistance between the two groups. Although 12 weeks walking improves aerobic capacity, it does not affect plasma adiponectin concentration in postmenopausal women with breast cancer