Macro- and micromorphology of the root, stem leaf, infloresence and fruit of Euphorbia peplus L. growing in Egypt

Euphorbia peplus L. belongs to Family Euphorbiaceae which includes about 283 genera with almost 7500 species. They are distributed all over the world mainly tropical countries. Some species of the genus Euphorbia showed antiviral and anticancer activities. It was reported to be used in folkloric medicine as purgative and in treatment of skin diseases, gonorrhea, liver disorders, chest diseases, and gout. Some phytochemical studies have been carried out abroad on different species. The authors carried out phytochemical and biological studies on the studied plant and here in we undertake macro- and micromorphological studies with the aim of finding out the diagnostic features by which the plant could be identified in both entire and powdered forms

Correlation of ghrelin, adiponectin and leptin to BMI and treatment outcome in breast cancer patients

Body mass index [BMI] is an independent prognostic factor for survival in breast cancer patients. Patients with higher BMI were found to have poorer cancer prognosis and lower survival rates. Many factors as ghrelin, adiponectin and leptin, have been implicated in obesity but their correlation with breast carcinogenesis and treatment outcome is still a debate.To identify the relation of ghrelin, adiponectin and leptin with BMI in breast cancer patients and their possible role in carcinogenesis and treatment outcome. Sera from 80 breast cancer patients were analyzed. Ghrelin, adiponectin and leptin were assayed by commercial RIA kits, and their levels were correlated with BMI, clinicopathological parameters and relapse-free survival. The median duration of patients' follow-up was 32 months.73.7% of the cohort was overweight/obese. Compared to breast cancer patients with normal BMI, overweight/obese patients had a significantly higher tumor size and higher histological grade. Overweight/obese patients had higher leptin and lower ghrelin and adiponectin levels. Adiponectin was lower in patients with higher tumor grade and lymph node involvement, while ghrelin decreased with increasing tumor size and histological grade. Only serum ghrelin levels were significantly correlated to better disease-free survival.Ghrelin, adiponectin and leptin are significant factors in controlling BMI in breast cancer patients but only ghrelin is a significant predictor of better outcome and recurrence-free survival

Study of pulmonary complications after post mastectomy radiotherapy in patients with cancer breast treated with or without simultaneous adjuvant anti - estrogen

Forty women who were treated with postmastectomy radiotherapy for breast cancer with or without adjuvant tamoxifen treatment were involved in this study. Postmastectomy radiotherapy cases showed slight restrictive ventilatory abnormalities in pulmonary functions, mainly in patients received tamoxifen treatment. The radiological abnormalities developed with postmastectomy radiotherapy were more often easily detected by high resolution computed tomography [HRCT] than by CXR and these abnormalities were significantly higher in patients received tamoxifen treatment. Postmastectomy radiotherapy encountered has in the form of pneumonitis early and late pulmonary lung fibrosis

Changing pattern of tuberculosis in Al Abbassia and Bab Al Shaaria regions in years 1994-1999

The study of routine work in Abbassia and Bab Al Shaaria Chest Dispensaries over the years 1994 1999, reveals the following: The number of subjects examined in both dispensaries was 92768 out of which 833 were diagnosed as tuberculous. The highest percentag of cases was found between age group of 20-40 years. Average percentage of disease in males was 72,9% and. 67.63% while in females was 27.1% and 32.37% in both Abbassia and Bab Al-Shaaria Chest dispensaries respectively. The average percentage of pulmonary TB in Abbassia chest dispensary was 88.89% and extrapulmonary TB percentage was 11.11% while in Bab Al-Shaaria Chest Dispensary the percentage of pulmonary TB was 83.56% and of extrapulmonary TB was 16.44%. The percentage of bronchogenic pulmonary TB was 68% and 65.54% in both Abbassia and Bab Al-Shaaria chest dispensary respectively, while primary pulmonary TB was 9.55% and 5.21% in both Abbassia and Bab Al-Shaaria chest dispensaries respectively. Pleural effusion percentage was 10.67% in Abbassia chest dispensary while ion Bad Al-Shaaria chest dispensary was 12.54% and of miliary TB lesion was 0.67% and 0.27% in both Abbassia and Bab Al-Shaaria chest dispensaries respectively. The number of defaulter cases in Abbassia chest dispensary was 141 cases [31.33%] and in Bab-Al-Shaaria chest dispeary was 39 cases [10.18%]. The relapse rate in Albassia chest dispensary was 3.89% and treatment failure rate was 7.11% while fatality rate was 6.14% but in Bab-Al-Shaaria chest dispensary the relapse rate was 4.06%, treatment failure rate 5.52% and the fatality rate was 2.90%

Synthesis of biologically active 3 bromo-1: 8-naphthalylamino acid dipeptide derivatives

Synthesis of a series of 3-bromo-l: 8-naphthalylamino acids [II-VIII] and their corresponding methyl esters [IX-XIII]is described. Coupling of 3-bromo-l: 8-naphthalylamino acids with amino acid methyl ester hydrochlorides [or urea or 2-amino-pyridine] in dioxane-DMF-Et, N medium using DCC method, furnishes the desired 3-bromo-l: 8-naphthalyldipeptides[XIV-XXVIII]. All 3-bromo-l-8-naphthalyl derivatives of L-valine, L-leucine, DL-phenylalamtie and [S-alanine and their methyl esters and most dipeptide derivatives were found to possess high antimicrobial activities towards different microorganisms