Compatibility study between ibuprofen, indomethacin, tolbutamide and glibenclamide and some tablet excipients using differential scanning calorimetry

Differential scanning calorimetry [DSC] was used to investigate the interactions between selected drugs; namely, ibuprofen, indomethacin, tolbutamide and glibenclamide, and a number of commonly used tablet excipients. Ibuprofen, tolbutamide and glibenclamide were found to interact with magnesium stearate and lactose, but no interaction was observed with the other excipients used. Indomethacin interacted only with lactose

In vivo fusigenicity of polyethylene glycols: Protective role and potential risk

Polyethylene glycols [PEGs] are widely used in pharmaceutical preparations inspite of their known potentin vitro fusigenic properties. The subject of this note is to demonstrate that similar fusion can take place when these agents are administered to laboratory animals. Fusigenicity as observed by direct microscopic examination, and alsoby monitoring protective activity that cell fusion provides against ulcer formation by indomethacin. Rectal or oral administration of PEGs was found to result in histological alterations, suggesting fusion of mucosal cells. Also, high molecular weight PEGs were found to provide the stomach with protection against indomethacin induced ulceration, following oral administration to rats

effect of particle size and concentration of polycarbophil on its physical properties and the pharmaceutical characteristics of prepared indomethacin tablets

The effect of varying the concentration of polycarbophil and particle size on its physical characteristics viz swelling, flowability and compressibility was investigated. The effect of using polycarbophil, in different concentrations of varying particle sizes, on the characteristics of indomethacin tablets prepared by direct compression was also studied. The swelling of polycarbophil increased as its particle size increased from <0.063 to 1 mm. The particles having particle size range 0.5-0.8, 0.8-1.0 and >1 mm showed excellent flowability. The amount of indomethacin released was found to decrease as the polycarbophil concentration and the particle size increase. The effect of polycarbophil particle size on the dissolution of indomethacin was more pronounced at 5% concentration. 20% polycarbophil, of particle size 0.18-0.8 mm, could be a useful additive in tablet formulation as disintegrant to its bioadhesive character