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New Egyptian Journal of Medicine [The]. 1996; 14 (5): 244-48
in English | IMEMR | ID: emr-42713

ABSTRACT

Plasma levels of atrial natriuretic peptide [ANP] were measured using a specific and sensitive radioimmunoassay in 40 children with nephrotic syndrome [NS]. Nine patients were steroid resistant and the remaining had primary steroid responsive NS. Renal biopsy was performed to four steroid resistant nephrotic patients and revealed membranoproliferative glomerulo nephritis [MPGN] in three patients and lupus nephritis in one patient. Plasma levels of ANP were also measured in 18 healthy children as a control group. High plasma concentrations of ANP were detected in nephrotic patients during active stage of the disease [edema and heavy proteinuria] irrespective to the underlying renal pathology or to the response to steroid therapy. Plasma ANP values in nephrotic patients correlated negatively with serum albumin and with serum creatinine clearance


Subject(s)
Humans , Male , Female , Nephrosis, Lipoid/blood , Atrial Natriuretic Factor/biosynthesis , Child , Nephrotic Syndrome/physiopathology
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