Synthesis and antimicrobial activity of some aminoacyl substituted cinnamic acid derivatives

The synthesis of different 4-chlorocinnamoylamino acids and the corresponding amino acid methyl esters, amino acid hydrazides, dipeptide methyl esters and dipeptide hydrazides [II-XXXVI] are described. Some of the synthesized compounds were found to possess antimicrobial activities towards different microorganisms

Synthesis and Antimicrobial activity of some new 3-amino-1,2,4-triazine amino acid derivatives

The synthesis of some 3-[N-tosyl- and N-phthaloylaminoacyl]amino-1, 2, 4-triazines [II-XIV] was described. Coupling of N-tosyl-or N- phthaloylamino acids with 3-amino-1, 2, 4-triazine using dicyclohexylcarbodiimide furnished the desired derivatives [II-XIV]. Hydrazinolysis of 3-[N-phthaloyl-Gly] aminotriazine [IX] in ethanol afforded the free amino-compound 3-[Gly] aminotriazine [XV]. Compounds XVI-XX were obtained under similar conditions. The different 3-[N-Tos-di- and tripeptidyl]aminotriazines XXI-XXVI were obtained via the azide method. Some of the prepared compounds were found to be active against a number of microorganisms

Synthesis and Antimicrobial activity of some new 2- [n-protected or free aminoacyl or N-phthaloyl-or n-tosyldipeptidyl] amino-4,6-dichloro- and 5-bromopyrimidine derivatives

Synthesis of some new 2-[N-phthaloyl-or N-tosylaminoacyl or free aminoacyl or N-phthaloyldipeptidyl or N-tosyldipeptidyl] amino-4, 6- dichloropyrimidines [III-XXI] and the corresponding derivatives of 5- bromopyrimidines [XXII-XL] was described. Some products were found to be active against a number of microorganisms

Synthesis and anti microbial activity of some pyrazine and disubstituted pymzine-amino acid derivatives

The synthesis and antimicrobial evaluation of some pyrazine-2-carbonylamino acid methyl esters III-VI, 3-hydroxy-5-methylpyrazine-2-carbonylamino acid methyl esters VII-X, the corresponding hydrazides XI-XVIII and some dipeptide methyl ester derivatives XIX-XXVI were described