Modulation of the antiepileptic activity of sodium valproate by lithium chloride against kainic acid and bicuculline-induced seizures

The influence of lithium chloride on the anticonvulsant activity of sodium valproate [VAL] was evaluated against two chemically-induced convulsive seizures; namely, bicuculline [BIC] and kainic acid [KAA]. Both drugs were given i.p., either singly or in combination to groups of mice [n = 8] and were allowed to act for 30 minutes before the chemical induction of seizures. Valproate was used in doses of 200 and 300 mg/kg [its ED50 against the specific convulsive agent] against BIC and KAA, respectively, whereas lithium chloride was used in a dose of 10 mg/kg. Then, convulsions were induced by i.p. injection of kainic acid [KAA, 70 mg/kg] and bicuculline [BIC, 1 mg/kg]. The animals were observed over a period of 40 minutes for the onset of convulsions. The mean survival time [MST] and the percentage of animals protected from death produced by each convulsive agent were computed. In conclusion, the present study suggested that the anticonvulsant action of sodium valproate against BIC and KAA-induced seizures may be partially augmented by the concurrent use of lithium chloride and this could be explained, at least in part, by the effect of lithium on the electrolyte levels caused by valproate

CNS and anti-inflammatory activities of fifteen newly synthesized quinazelinone compounds in mice and rats

In this work, a pharmacological study was carried out using 15 newly synthesized quinazolinone compounds. The effect of these compounds on CNS activity of mice and rats was accomplished following their ip injection into them. All compounds were suspended in 5% aqueous Suspension of gum acacia and were given into mice in a dose of 60 mg/kg. The central effects of 15 well-selected quinazolinone compounds were evaluated. This pharmacological study revealed the effectiveness of many quinazolinone derivatives against spastic and convulsive disorders as well as their activity as sedative hypnotics and anti-inflammatory agents

Changes in Gastrin-17 level associated with helicobacter pylori colonization in dyspeptic patients with and without ulcer formation

Ninety patients with dyspeptic symptoms in the form of heart-burn, epigastric pain, nausea, vomiting and feeling of fullness were classified into: Group 1, 30 patients with cirrhotic liver, portal hypertension and esophageal varices, Group 2, 30 patients with gastric or duodenal ulcers, Group 3, 30 patients with normal endoscopic gastric mucosa [non-ulcer dyspepsia]. Upper gastroscopy and 3 biopsies from the antrum were taken from all cases. CLO test for detection of H. pylori infection and histopathology of the biopsies were done

Delta virus versus HBsAg in chronic active hepatitis and their relation to clinical, laboratory, and morbidity findings in bilharzial and non-bilharzial patients

This work was done to study the effect of delta virus and HBV infection, as two etiological factors on clinical presentation, biochemical liver functions and prognosis of chronic active hepatitis [CAH] in schistosomiasis infected and non-infected patients. 66.7% of the patients were carriers for HBsAg, among them 41.7% were infected with delta virus. It was evident that the clinical presentation of the patients with positive serological markers of HBV and HDV demonstrated advancing liver disease than in the other studied groups. Moreover, the biochemical liver profile was significantly affected when the triad of chronic HBV, delta virus and schistosomiasis infection was present. This could be related to the immunosuppression caused by schistosomal infection. Furthermore, mortality rate was significantly higher in schistosomiasis infected individuals

Decay dynamics of fenvalerate in mentha piperita L and in the resulting oil

A synthetic pyrethroid, fenvalerate [alpha-cyano-3-phenoxy-benzyl alpha-Isopropyl-4-chlorophenylacetate.] was applied to peppermint plants. The residues were determined in peppermint herb and in the resulting oil at different intervals after spraying. Gas-liquid chromatographic analysis was performed on a 5% OV-101 AW/CW with[63] Ni electron capture detection. Fenvalerate recovery was 90% when added at the 5 ppm level. Tracing the residue data are indicated hereafter