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EMHJ-Eastern Mediterranean Health Journal. 2002; 8 (1): 105-113
in English | IMEMR | ID: emr-158045

ABSTRACT

We compared the estradiol/progesterone-induced luteinizing hormone [LH] and follicle-stimulating hormone [FSH] release between normally fed and leptin-supplemented starved ovariectomized female rats and studied also the effect of hyper-leptinaemia on the steroid-induced hormonal release in normally fed ovariectomized rats. Three days' starvation completely abolished steroid-induced LH and FSH release. Significant recovery of the hormonal release was shown in the leptin-supplemented starved group. The magnitudes of LH and FSH release in the normally fed animals with a higher dose of leptin were statistically the same as those in the normally fed group without leptin. These observations indicate that physiological concentrations of circulating leptin exert a stimulatory effect on steroid-induced LH and FSH release


Subject(s)
Animals , Female , Analysis of Variance , Disease Models, Animal , Follicle Stimulating Hormone/metabolism , Hypothalamo-Hypophyseal System/drug effects , Luteinizing Hormone/metabolism , Neuropeptide Y/drug effects , Ovariectomy , Rats
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