ABSTRACT
The gastrointestinal absorption of sulfamethazine sodium in rats was studied in presence and in absence of capsaicin. The absorption was evaluated by the pharmacokinetic analysis of the plasma levels of sulfamethazine following its oral administration. Capsaicin was found to increase the rate constant of absorption and the AUC of the plasma levels versus time, without changing the rate constant of elimination
Subject(s)
Sulfamethazine , Intestinal Absorption , RatsABSTRACT
The effect of single doses of capsaicin on the bleeding time was studied in unanaesthetized rats. The obtained results show that capsaicin prolongs the bleeding time significantly. Results are discussed in view of the possible consequences of the observed effects
Subject(s)
Platelet Function Tests , Animals, LaboratoryABSTRACT
The effect of insulin on absorption of sulfathiazole from the buccal cavity was studied in volunteers of both sex. Insulin was shown to increase the amount absorbed, and to change significantly the rate constant of absorption [Ka] and the half life of the fraction remaining of sulfathiazole in the buccal cavity [t ']. The obtained results are in agreement with previously done works on laboratory animals. The results illustrate the usefulness of the buccal absorption model for studies on drug interaction during absorption
Subject(s)
Sulfathiazoles , Drug InteractionsABSTRACT
The effect of capsaicin on mixed function oxidases was studied by use of liver homogenates of adult female rats. Hydroxylation of biphenyl was taken as the assay system. Capsaicin was found to produce a prominent concentration-dependent activation of the 4-hydroxylation reaction. The 2-hydroxylation reaction showed an inhibition in presence of capsaicin. The results indicate that capsaicin may interact with more than one form of cytochrome P. 450