Histological evaluation of the pulp of primary teeth after pulpotomy with formocresol and SUAB2

Formocresol is a popular pulpotomy medicament in primary dentition. Because of its systemic and local side effects, it may be essential to use another material instead of formocresol. The purpose of this study was to assess the pulpal response after pulpotomy histologically with two different agents; namely, formocresol and SUAB2. In this randomized clinical trial study, 14 teeth of seven children that should had been extracted because of orthodontic treatment were selected. These teeth were randomly divided into two formocresol and SUAB2 [Shahed University Anti Bleeding 2] groups. Seven teeth were pulpotomized with formocresol and seven teeth with SUAB2. These teeth were extracted after 2 months and the pulpal response was evaluated. Finally, the data were analyzed with exact fisher and Mann-Whitney tests. In the formocresol group, severe inflammation was seen in four teeth, mild inflammation in three teeth, abscess in four teeth, necrosis in two teeth, fibrosis in three teeth and internal resorption in four teeth. In the SUAB2 group, severe inflammation was not seen. Moderate and mild inflammation was seen in four teeth, abscess in two teeth, necrosis in two teeth, fibrosis in three teeth and internal resorption in four teeth. Mann-Whitney test revealed that inflammation is significantly less in the SUAB2 group compared with the formocresol group [p<0/05]. Based on the results of this study, SUAB2 may be used in primary teeth pulpotomy

[Histopathological evaluation of pulp changes after ferric sulfate and formocresol pulpotomy in primary teeth]

Formocresol is an inrtacanal medicament commonly used for pulpotomy in the primary dentition. Because of its toxic and carcinogenic potential, it has been challenged by other chemical treatments. The purpose of this study was to histologically assess the pulpal healing process in pulpotomized primary teeth, using two different agents: formocresol and ferric sulfate. A total of 16 primary cuspids [8 pairs] from 8 patients who were scheduled for orthodontic extraction were selected and randomly divided into 2 groups. One tooth from each pair of contralatcral teeth was assigned to either formocresol or ferric sulfate pulpotomy. Four pairs were extracted after 1 month and the other 4, after 2 months. Pulpal response was determined according to the degree of inflammation and extent of pulpal involvement. Dentinal bridge formation was also evaluated. The data were analyzed using Wilcoxon test. No significant difference was found between the two groups for inflammation, absecess, root resorption and dcntinal bridge formation. Necrosis was more extensive in the formocresol pulpotomy group [p<0.05]. Based on these results, formocresol can be substituted with ferric sulfate for pulpotomy of primary teeth

[Effect of nucleus paragigantocellularis destruction on Caffeine and Naloxone withdrawal sings precipitations in male rats]

It is showed that the activity of paragiganocellularis [PGi] nucleus is diminished in addict animals, but in contrast this activity was augmented during withdrawal period. Also, regarding interrelation of opiate and adenosine systems, it was obvious that in each system not only the specific antagonists but also the contrast antagonists system could produce withdrawal signs. In this study the role of PGi nucleus in precipitation of withdrawal signs induced by opiate and adenosine antagonists was investigated. In this experimental study, dependency was induced by escalating doses of morphine via drinking water which were prescribed to the animals during a 21 days period. Then addicated rate were subjected to four groups: 1-Intact 2-Sham 3-unilateral PGi destruction and 4-bilateral PGi destruction. Withdrawal signs were induced by 1-Naloxone [2 mg/kg sc.] and 2-Caffeine [50 mg/Kg ip.] administration in each group. Data was gathered and then analyzed using one way ANOVA, Tukey and Chi square tests. P< 0.05 was considered significant. Naloxone withdrawal signs were consisted of diarrhea, ejaculation, teeth chattering, ptosis, irritability, wet dog shake, strop tail, jumping and weight loss. Following bilateral PGi destruction there was a marked attenuation in three signs of irritability, teeth chattering and jumping sings. The number of withdrawal signs which were produced by Caffeine administration were less than Naloxone [diarrhea, ejaculation, teeth chattering, chewing, irritability and jumping]. However, destruction of PGi nucleus [bilateral] diminished four sgins including: diarrhea, ejaculation teeth chattering, and irritability. The present study showed that the withdrawal signs precipitated with Caffeine are less different than Naloxone, and the bilateral PGi destruction could markedly attenuate these sings in Caffeine group more than Naloxone ones