Testing bromocriptine dose necessary for suppression of lactation in rats: morphological study

The lowest dose of bromocriptine, necessary for suppression of lactation in rats, was estimated in this investigation. Fifty healthy lactating rats were treated with different doses of bromocriptine. Cessation of lactation was assessed clinically and histologically. Revealed that the lowest dose capable of lactation suppression is 4 mg bromocriptine / kg body wt. / day. It is very important to know the exact dose, which can suppress lactation in rats because these laboratory animals are commonly employed in experiments concerning this topic

demonstration of B-esterase in the dorsal gery horn of the rats spinal cord during pain and analgesia

The B-esterase technique has been utilized as a cheaper and less sophisticated technique than the immuno-histochemical method for the demonstration of substance P prevalence sites at the dorsal grey horn of the spinal cord of rats. B-esterase reaction product was abundant at laminae I and II of dorsal grey horn during the induction of pain while analgesia reduced the activity of this enzyme at the same sites