ABSTRACT
The study was carried out on 40 male albino rats [a fed group and a starved group]. Half of the animals in each group received intravenous injection [1.5 ng/g b. wt.] for 4 consecutive days. Glucagon treatment prevented starvation induced sodium retention and was observed to enhance the glomerular filtration rate [GER] and to lack an influence on the renal Na+ - K+ ATPase enzyme. So, it can be concluded that the natriuretic action of glucagon can be considered to be performed at the glomerular level
Subject(s)
Animals, Laboratory , Male , Glucagon/pharmacology , Starvation/enzymologyABSTRACT
To evaluate the effect of pharmacologic vasodilators on glycerol induced acute renal failure, we studied untreated animals and those given Diltiazem and Captopril at a period of 24 hours 3 days and seven days after the onset of acute renal failure. At each time comparative assessment of renal histology were performed. Diltiazem a calcium channel blocker significantly reduced the extent of tubular cell necrosis and was associated with a more rapid histologic recovery. Captopril, an angiotensin converting enzyme inhibitor, did not influence renal pathology throughout the observation period. Diltiazem was benificial and offered significant protection against glycerol-induced acute renal failure in rats; it may have a protective effect at least in early stages of acute renal failure in humans
Subject(s)
Animals, Laboratory , Drug Therapy , Diltiazem/pathology , RatsABSTRACT
The transverse pancreatic segment was transplanted from donor dogs to alloxan-diabetic recipient dogs determined by leukocyte cross-matching test. Nine transplantations were performed of which 4 dogs received. Octreotide [somatostatin derivative] therapy that gave marked improvement of the survival, local surgical results and diabetes control, in comparison to the other 5 dogs that did not receive the drug. This is attributed to suppression of the exocrine component of the transplanted segment