Synthesis of 2-alkoxy-3cyano-4,6-diarylpyridines as antibacterial agents

Two facile synthetic methods were adopted for the preparation of new series of 2-alkoxy-3-cyano-4, 6-diarylpyridines VI-Xa-e. The first involved the reaction of substituted chalcones with malononitrile in sodium alkoxide-alcohol system. The second reacted the arylidene malononitrile XI, XII with the appropriate aryl methyl ketones XIII-XV in sodium alkoxide-alcohol system. The two methods gave good yields of the target compounds VI-Xa-e. Representative examples of the newly synthesized compounds were evaluated for antibacterial activity