Value of estimating intraocular antiboddy production in diagnosi of typical and atypical lesions of ocular toxoplasmosis

Serum and aqueous humor [AH] samples were collected from 45 patients: 20 with typically active or reactivated retinal lesions of Toxoplasma [group I], 16 with atypical lesions [group II] and 9 with old quiescent scars [group III]. Also, serum and AH samples were collected from 10 patients with chronic toxoplasmosis without any ocular manifestation [group IV]. T. gondii specific IgG, IgA and IgM antibodies were measured by ELISA in AH and serum and the intraocular [local] antibody production was determined by calculating Goldman- Witmer coefficient [GWC]. IgG antibodies were the only class detected in all sera of patients with ocular and nonocular toxoplasmosis. An intraocular IgG antibody synthesis was confirmed in 95% and 37.5% of patients with typical [group I] and atypical [group II] posterior uveitis, respectively, and in no one of either patients with quiescent scars [group III] or the ophthalmologically free patients [group IV]. As regards the typical active lesions, the sensitivity of the IgG assay [95%] was higher than that of IgA [60%] and IgM [5%] assays

Topical 5-fluorouracil versus mitomycin-c in management of pterygium

44eyes primary pterygia were treated by surgical excision with bare sclera 2 - 3 mm followed by topical instillation of 0.02% mitomycin-c twice daily for 5 days [20eyes], and 5-Fluoro uracil 4 times for 2 weeks [24 eyes]. Both medications reduce the recurrence rate of pterygia. To 5% in cases treated with mitomycin-c and 8.3% in cases treated with 5-fluoro-uracil after 6 months follow-up period. The result of the study showed that mitomycin-c is more effective than 5-Fluoro uracil, better tolerated by the patients and with Lesser complications