ABSTRACT
Many growth factors have been shown to be included during fetal life. Insulin and insulin-like Growth factor-I [IGF-I] are important factors, that have major influence on fetal weighl gain and post-natal growth. In this study, we detennined the levels of cord blood insulin and insulin-like growth factor-I, in 40 healthy full term neonates, with its effect on their anthropometric measurements [head circumference, length, body weight] and gestational age. The studied neonates were delivered in Bab EI-Sharia Hospital, AI-Azhar university either by NVD [n=22] or by C.S [n= 18]. They were 24 males and 16 females. They delivered to healthy mothers [without D.M or any medical problems]. The neonates were classified according to their birth weight, maturity, and appropriance for gestational age into: 15 large for gestational age [LGA], 15 small for gestational age [SGA] and 10 appropriate for gestational age [AGA] as control group. Data concerning all neonates were recorded including: Mode of delivery and APGAR score. Meticulous clinical examinations to all body systems to exclude any abnormality if present Birth measurements were taken and recorded [birth weight, head circumference length and ponderal index] nsulin was measured by immunoradiometric assay and IGF-1 by radioimmuno-assay [R1A] techniques. Also, cord blood glucose was measured in all studied cases and controls. There were highly significant differences between LGA, SGA groups and AGA control group as regard birth weight, length, H, C and gestational age [p<0.01]. Also, there was significant increase in cord bl. IGF-I in LGA group as compared to AGA group [p<0.01], but no significant difference between cord bl. glucose, and cord. bl. insulin in either LGA group or SGA group compared to AGA group [p>0.05]. There were positive correlations between IGF-I and body weight, H.C and length. p<0.001 There was a positive correlation between cord bl. IGF.I and cord. bl. insulin [p<0.01]. But a negative correlation was found between cord bl. IGF-I and cord. bl. glucose [r=-0.416] [p<0.01]. There were no significant difference between LGA, SGA and control group [AGA] as regard APGAR .score, cord bl. glucose or cord bl. insulin [p>0.05]. As. regard gender discrimenation and mode of delivery, there were no correlations or significant difference in either cord blood IGF-I nor cord bl. insulin