Experimental study using cinnamon oil for prevention of diabetic nephropathy in rats

Diabetes mellitus is the leading cause of chronic renal failure. However, in the early phase of the disease before complications have set in, the glomerular filtration rate is elevated and kidney size increased. The clinical importance of these early aberrations derives from the hyperfilteration [the heightened glomerular capillary] that drives damages the glomerulus, and the enlargement of the kidney [the glomerulus]. The aim of the present investigations is to examine histologically the effect of cinnamon oil on the kidney tissues of alloxan - induced diabetes rats. Fifty male rats were used and divided into four groups: Group I =12 animal controls, Group II =12 treated with alloxan, Group III = 12 treated with alloxan + cinnamon oil, Group IV = 12 treated with cinnamon oil only. Renal tissues [Bowman's capsule, proximal and distal convoluted tubules] of diabetes group: revealed obvious mesangial expansion and basement membrane thickening. While the diabetic treated animals with cinnamon oil ameliorated the increase in the mesangial area in diabetic rats. Cinnamon oil can be recommended as an support for the prevention of alloxan - induced diabetic complications

role of cinnamon oil on renal tissue of hamster following alloxan - induced diabetes . histochemical approach

Diabetes mellitus is a heterogeneous group of disorders characterized by abnormalities in carbohydrate, protein, and lipid metabolism, which is due either to insulin production or action. Diabetes is a leading cause of blindness, kidney disorders, disease of small blood vessels and various other malfunctions. So the of this study is to investigate the effect of cinnamon oil as a natural source of a wide scale of antioxidants on prevention and treatment of oxidative stress in alloxan - induced diabetic animals, through biochemical and histochemical studies. Thirty - five hamsters were employed in ttes study. They wre divided into 4 groups. 1[st] gioup '. 5 -animal control, 2[nd] group :10 = treated with alloxan, 3[rd] group, 10 = treated with cinnamon oil and 4[th] group, 10 = treated with alloxan and cinnamon. Renal tissues [Bowman's capsule, proximal and distal convoluted tubules] of alloxan - treated group revealed obvious increase in acid [ACP] and alkaline [ALP] phosphatase activity. While the 4 group showed clear decrease in the activity of these enzymes as compared with group I and group III. Cinnamon-oil can be recommended as an support for the prevention of alloxan - induced diabetic complications

antagonistic role of cinnamon on a destructive effect of alloxan on the rat testis a histological study

Diabetes mellitus is a chronic metabolic disorder characterized by a high blood glucose concentration [hyperglycemia] which is due to insulin deficiency and / or insulin resistance. As a consequence of the metabolic derangements various complications develop, so the aim of this investigation is to study [histological] the role of cinnamon - oil on the testis tissue of alloxan -induced diabetes rat. Forty -six male rats were used and divided into 3 groups : group 1,6= animal control. group II, 20 = treated with alloxan and the 3[rd] group, 20 = treated with alloxan + cinnamon. Testis of group I revealed normal distribution of seminiferous tubules and spermatozoa filled the lumen of these tubules. Group II showed reduction in number of seminiferous tubules, and absence of spermatozoa in their lumen, besides the significant decrease in testis weight. Group III elicited retrained these changes to approximately its normal view. This herbs [cinnamon] decrease or protect the destructive effect of alloxan on testis tissue