Protective effect of nutritional formula during chemotherapy of driamycin in rats

Adriamycin [ADR], an anthracycline, is widely used in the treatment of a variety of human malignancies, causes various toxic effects. The present study was designed to investigate the possible therapeutic effect of a new antioxidant formulae [Garlic, Se, Mg and vitamin E] in ameliorating adriamycin-induced red blood cell, cardio- and hepato-toxicities and elevation ofglucose-6-phosphate dehydrogenase [G6PD] activity of red cell in rat. Five groups of six rats each were used. Rats of the first group serve as control and were fed on basal diet. Groups 2, 3, 4, 5 were treated by intra-peritoneal adriamycin [5mg/Kg/three times/two weeks]. Rats of group 2 were fed on basal diet, while the rats of groups 3, 4 and 5 were fed on basal diet containing the antioxidant formula used with different levels. Our results showed that blood hemoglobin level was significantly reduced in ADR-treated group and that supplementation of antioxidant formula restored its level almost to the normal control. Significant decrease [p<0.05] was observed in Glutathione peroxidase [GSH-Px] and G6PD activities in ADR group compared to control while, supplementation of antioxidant formula among rats of groups 3, 4 and 5 significantly increased its levels compared to ADR group. Significant increase [p<0.05] in malondialdehyde [MDA] was observed in heart, liver, spleen and plasma of ADR rats group compared to control. However, administration of adriamycin to rats fed diet containing antioxidant formula the increase in MDA was less than that produced by adriamycin in rats fed normal diet. In conclusion, supplementation of the formulae containing garlic, Se, vit. E and Mg may prevent or reduce adriamycin-induced oxidative stress in red blood cell, liver and heart through enhancement of antioxidant enzymes [GSH-Px and G6PD] and reduction of malondialdehyde

Epidemiological study of breast masses in relation to Histo-pathological profiles, El-Minya, Egypt

Breast lesions usually take the form of palpable masses, sometimes painful, more often not. The epidemiological study of cancer breast could give a clue to the possible risk factors. This case series study was done on 296 cases with breast lesions randomly chosen. Benign and malignant masses of the breast are virtually limited to the females. In benign masses, fibro-adenosis is the commonest type [44.2%] and duct papilloma is the least common one [4.6%]. Fibro- adenosis was common in unmarried and nulliparous women [17.5% and 16.6%, respectively], while women have more than four children have the lowest incidence [5.9%]. Fibro-adenosis was common in women taking no pills [18.4%]. Benign lesions was common in the 4th decade, the mean age was 33.5 +/- 8.3 years and painless swellings were common with relevant past and family history [X 2 + 65 and P <0.05]. The right breast was the commonest site [58.5%] and estrogen level was highly significantly increased in fibro-adenosis [P <0.001]. Uterine tumors were commonly associated with fibro-adenosis [11.3%]. In malignant masses, infiltrating duct carcinoma was the commonest [77.2%], it is common in unmarried and nulliparous women [15.2% and 24.1%, respectively]. There is no significant difference in women with malignant masses taken or not taken pills [X 2= 8.4 and P >0.05]. The mean age of malignant lesions was 44.5 +/- 8.7, painless swellings were common and right breast was the commonest site of masses [63.3%]. Estrogen level was highly significantly increased in infiltrating duct carcinoma [P <0.001]. Also, uterine tumors were commonly associated with infiltrating duct carcinoma [7.6%]